Brunelli Susan A
Department of Developmental Psychobiology, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York 10032, USA.
Dev Psychobiol. 2005 Nov;47(3):243-52. doi: 10.1002/dev.20090.
Mother-infant separation in the rat has been used as an analytical tool to reveal biosocial processes underlying infant physiology and behavior. The same strategy has guided a project in which selective breeding for an infantile behavior has provided insights into how biological systems become recruited and integrated as expressions of temperamental affective responses. Two lines of rats (High and Low USV lines) were selectively bred based on rates of USV emission to maternal separation and isolation at postnatal day (P) 10. After many generations of breeding, the High and Low lines show widespread and distinctly different profiles of physiology and behavior in the first 3 weeks of life. Insights gained from longitudinal studies suggest that selection may work by reorganizing developmental processes, not just a given trait, over the postnatal period. As animal models, the lines have the potential to provide valuable tools for understanding developmental mechanisms underlying genetic and developmental risk for depression/anxiety syndromes in children and adults.
在大鼠中，母婴分离已被用作一种分析工具，以揭示婴儿生理和行为背后的生物社会过程。同样的策略指导了一个项目，其中针对婴儿行为的选择性育种提供了有关生物系统如何作为气质性情感反应的表现而被招募和整合的见解。根据出生后第10天（P10）时对母婴分离和隔离发出超声波发声（USV）的比率，对两系大鼠（高USV系和低USV系）进行了选择性育种。经过多代繁殖后，高系和低系在出生后的前3周表现出广泛且明显不同的生理和行为特征。纵向研究获得的见解表明，选择可能是通过在出生后时期重组发育过程而起作用的，而不仅仅是针对某一特定性状。作为动物模型，这些品系有可能为理解儿童和成人抑郁/焦虑综合征的遗传和发育风险背后的发育机制提供有价值的工具。
