可能改变分居饲养大鼠吗啡镇痛作用的因素。
Factors which might modify analgesic effect of morphine in differentially housed rats.
作者信息
Czlonkowski A, Kostowski W
出版信息
Pol J Pharmacol Pharm. 1977 Mar-Apr;29(2):117-21.
PMID:16253
Abstract
The analgesic effect of morphine was studied by tail compression method in grouped and chronically isolated Wistar male rats developing muricide behavior showed increased pain threshold whilst indifferent (non-killer) showed reduced responses to the analgesic action of morphine. "Natural" killer (housed in groups) showed, on the other hand, increased sensitivity to morphine. The role of factors such as isolation period, behavioral pattern and contact with the victim was discussed.
摘要
采用尾部压迫法，对群居及长期隔离的雄性Wistar大鼠的杀鼠行为进行了研究，发现有杀鼠行为的大鼠痛阈升高，而无杀鼠行为（非杀手型）的大鼠对吗啡镇痛作用的反应减弱。另一方面，“天然”杀手型（群居）大鼠对吗啡的敏感性增强。文中还讨论了隔离期、行为模式及与受害者接触等因素的作用。
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