吗啡在群居及单独饲养的大鼠和小鼠中的作用。
Morphine action in grouped and isolated rats and mice.
作者信息
Kostowski W, Czlonkowski A, Rewerski W, Piechocki T
出版信息
Psychopharmacology (Berl). 1977 Jul 18;53(2):191-3. doi: 10.1007/BF00426491.
The present study determines the analgesic effects of morphine in grouped and isolated rats and mice. Isolated animals developed altered behavioral patterns, including mouse-killing in rats and mutual aggressiveness in mice. The analgesic effect of morphine was tested by tail compression in rats and by the hot plate for mice. Isolated rats developing mouse-killing behavior had a raised pain threshold, while indifferent animals (nonkillers) responded less to morphine. Isolated mice, particularly low aggressors, gave enhanced responses to morphine.
本研究确定了吗啡对群居及隔离饲养的大鼠和小鼠的镇痛作用。隔离饲养的动物出现了行为模式改变，包括大鼠的杀鼠行为和小鼠的相互攻击行为。通过对大鼠进行尾部压迫以及对小鼠使用热板法来测试吗啡的镇痛效果。出现杀鼠行为的隔离饲养大鼠痛阈升高，而无此行为的动物（非杀鼠者）对吗啡的反应较小。隔离饲养的小鼠，尤其是攻击性较弱的小鼠，对吗啡的反应增强。
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