Bond Alyson J
Division of Psychological Medicine, National Addiction Centre, PO 48, Institute of Psychiatry, King's College London, De Crespigny Park, UK.
Eur J Pharmacol. 2005 Dec 5;526(1-3):218-25. doi: 10.1016/j.ejphar.2005.09.033. Epub 2005 Oct 25.
Aggressive behaviour is associated with negative mood and poor impulse control. Serotonin has been specifically associated with impulse regulation and deficiencies in serotonin have been linked to impulsive aggression. However, aggression occurs in a social context and noradrenaline has been implicated in social motivation. Both serotonergic and noradrenergic antidepressants may therefore be effective in reducing aggression. The evidence for the effects of antidepressants on aggression comes from a wide range of sources but there are few controlled trials or experimental studies. Current findings point to decreases in negative mood and anger attacks and positive changes in personality traits after antidepressant treatment. Clinical studies in personality disorder patients have shown some efficacy for serotonergic antidepressants in reducing irritability and impulsive aggression. Experimental work in healthy volunteers has shown both serotonergic and noradrenergic antidepressants to increase assertiveness and affiliative behaviour. Both may therefore decrease aggression through different routes.
攻击性行为与负面情绪及冲动控制能力差有关。血清素一直特别与冲动调节相关，血清素缺乏与冲动性攻击行为有关。然而，攻击行为发生在社会环境中，去甲肾上腺素与社会动机有关。因此，血清素能和去甲肾上腺素能抗抑郁药可能都对减少攻击行为有效。抗抑郁药对攻击行为影响的证据来源广泛，但对照试验或实验研究较少。目前的研究结果表明，抗抑郁药治疗后负面情绪和愤怒发作减少，人格特质有积极变化。对人格障碍患者的临床研究表明，血清素能抗抑郁药在降低易怒性和冲动性攻击行为方面有一定疗效。在健康志愿者身上进行的实验表明，血清素能和去甲肾上腺素能抗抑郁药都会增加坚定性和亲和行为。因此，两者可能通过不同途径减少攻击行为。
