可靠的社会关系可预测II期和III期乳腺癌患者的总体生存率。

Dependable social relationships predict overall survival in Stages II and III breast carcinoma patients.

作者信息

Weihs Karen L, Simmens Samuel J, Mizrahi Joan, Enright Timothy M, Hunt Martha E, Siegel Robert S

机构信息

Department of Psychiatry and Behavioral Sciences, George Washington University Medical Center, Washington, DC, USA.

出版信息

J Psychosom Res. 2005 Nov;59(5):299-306. doi: 10.1016/j.jpsychores.2004.12.002.

DOI:10.1016/j.jpsychores.2004.12.002

PMID:16253620

Abstract

OBJECTIVE

The effect of support, from dependable non-household relationships, on breast cancer progression was studied using a prospective, longitudinal design.

METHODS

Dependable social support was assessed in women with invasive breast carcinoma Stages II and III within 18 months after diagnosis. Disease outcome was monitored for 8 to 9 years. Cox regression analyses, including the Nottingham Prognostic Index (NPI) score of disease severity, tested the association between the number of dependable support persons and time to death.

RESULTS

Ninety participants listed between 1 and 16 dependable nonhousehold support persons (mean = 6, S.D. = 4). There were 21 recurrences and 16 deaths from breast cancer at the end of the study. The number of dependable supports predicted decreased mortality [RR = 0.41 (0.21-0.80), P = .01] after controlling for NPI. NPI predicted increased mortality [RR = 1.6 (1.0, 2.4), P = .05].

CONCLUSIONS

For patients with Stages II and III breast cancer, the number of dependable, nonhousehold relationships predicts decreased mortality, after accounting for disease severity.

摘要

目的

采用前瞻性纵向设计，研究来自可靠的非家庭关系的支持对乳腺癌进展的影响。

方法

在诊断后18个月内，对II期和III期浸润性乳腺癌女性的可靠社会支持进行评估。对疾病结局进行8至9年的监测。Cox回归分析，包括疾病严重程度的诺丁汉预后指数（NPI）评分，检验了可靠支持人员数量与死亡时间之间的关联。

结果

90名参与者列出了1至16名可靠的非家庭支持人员（平均=6，标准差=4）。研究结束时，有21例复发和16例死于乳腺癌。在控制NPI后，可靠支持的数量预测死亡率降低[风险比（RR）=0.41（0.21 - 0.80），P = 0.01]。NPI预测死亡率增加[RR = 1.6（1.0，2.4），P = 0.05]。