氟喹诺酮类药物一日预防用药在前列腺活检中的疗效。
Efficacy of 1-day prophylaxis medication with fluoroquinolone for prostate biopsy.
作者信息
Shigemura Katsumi, Tanaka Kazushi, Yasuda Mitsuru, Ishihara Satoshi, Muratani Tetsuro, Deguchi Takashi, Matsumoto Tetsuro, Kamidono Sadao, Nakano Yuzo, Arakawa Soichi, Fujisawa Masato
机构信息
Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe 650-0017, Japan.
出版信息
World J Urol. 2005 Nov;23(5):356-60. doi: 10.1007/s00345-005-0024-4. Epub 2005 Oct 28.
A prospective, randomized trial in which 236 patients received oral levofloxacin, either at 600 mg/day for 1 day (n = 124) or 300 mg/day for 3 days (n = 112). Urinalysis, plasma white blood cell count (WBC) (per mm3), and C reactive protein (CRP) (mg/dl) levels were checked before prostate biopsy (PBX), on the day after PBX, and on the seventh day after PBX. Two patients (1.61%) who received 600 mg for 1 day and 2 patients (1.79%) who received 300 mg for 3 days had febrile infectious complications. There was no statistically significant difference between levofloxacin at 600 mg for 1 day and levofloxacin at 300 mg for 3 days regarding the elevation of WBC and CRP. We can perform PBX safely with levofloxacin at 600 mg for 1 day as prophylaxis and recommend this method from the point of view of the decrease of antibiotic-resistant strains.
一项前瞻性随机试验，236例患者接受口服左氧氟沙星，其中124例患者每天服用600毫克，共服用1天；112例患者每天服用300毫克，共服用3天。在前列腺活检（PBX）前、PBX后第1天和PBX后第7天检查尿液分析、血浆白细胞计数（WBC）（每立方毫米）和C反应蛋白（CRP）（毫克/分升）水平。1天服用600毫克的2例患者（1.61%）和3天服用300毫克的2例患者（1.79%）出现发热性感染并发症。在白细胞和CRP升高方面，1天服用600毫克的左氧氟沙星与3天服用300毫克的左氧氟沙星之间无统计学显著差异。我们可以将1天服用600毫克的左氧氟沙星作为预防措施安全地进行PBX，并从减少抗生素耐药菌株的角度推荐这种方法。
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