Tagaya M, Matsumoto M, Kitagawa K, Niinobe M, Ohtsuki T, Hata R, Ogawa S, Handa N, Mikoshiba K, Kamada T
First Department of Internal Medicine, Osaka University Medical School, Japan.
Life Sci. 1992;51(4):253-9. doi: 10.1016/0024-3205(92)90083-2.
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
