Arai T, Watanabe K, Nakao S, Mori H, Murakawa M, Mori K, Tooyama I, Kimura H, Kojima S
Department of Anesthesia, Kyoto University Hospital, Japan.
Neurosci Lett. 1994 May 23;173(1-2):107-10. doi: 10.1016/0304-3940(94)90160-0.
The effects of neopterin on ischemic neuronal damage were examined. Cerebral ischemia was produced in the gerbil by bilateral common carotid occlusion for 8 min or unilateral occlusion for 30 min, which resulted in delayed neuronal death in the CA1 region of the hippocampus. However, preischemic treatment with neopterin (3 mg/kg i.p.) markedly reduced hippocampal neuronal damages in both cases. Since neopterin serves both as an antioxidant and as an oxidant depending on its redox state, these findings indicate that neopterin attenuates the ischemic neuronal injury by scavenging oxygen free radicals and/or by inhibiting their generation.
研究了新蝶呤对缺血性神经元损伤的影响。通过双侧颈总动脉闭塞8分钟或单侧闭塞30分钟在沙鼠中造成脑缺血，这导致海马CA1区神经元延迟死亡。然而，缺血前用新蝶呤（3mg/kg腹腔注射）治疗在两种情况下均显著减少了海马神经元损伤。由于新蝶呤根据其氧化还原状态既作为抗氧化剂又作为氧化剂，这些发现表明新蝶呤通过清除氧自由基和/或抑制其生成来减轻缺血性神经元损伤。
