Motterlini Roberto, Mann Brian E, Foresti Roberta
Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK.
Expert Opin Investig Drugs. 2005 Nov;14(11):1305-18. doi: 10.1517/13543784.14.11.1305.
Carbon monoxide (CO), which is formed in mammalian cells through the oxidation of haem by the enzyme haem oxygenase, actively participates in the regulation of key intracellular functions. Emerging evidence reveals that an increased generation of haem oxygenase-derived CO plays a critical role in the resolution of inflammatory processes and alleviation of cardiovascular disorders. The authors have identified a novel class of substances, CO-releasing molecules (CO-RMs), which are capable of exerting a variety of pharmacological activities via the liberation of controlled amounts of CO in biological systems. A wide range of CO carriers containing manganese (CORM-1), ruthenium (CORM-2 and -3), boron (CORM-A1) and iron (CORM-F3) are currently being investigated to tailor therapeutic approaches for the prevention of vascular dysfunction, inflammation, tissue ischaemia and organ rejection.
一氧化碳（CO）在哺乳动物细胞中由血红素加氧酶氧化血红素形成，它积极参与关键细胞内功能的调节。新出现的证据表明，血红素加氧酶衍生的CO生成增加在炎症过程的消退和心血管疾病的缓解中起关键作用。作者已经鉴定出一类新型物质，即一氧化碳释放分子（CO-RMs），它们能够通过在生物系统中释放可控量的CO发挥多种药理活性。目前正在研究多种含锰（CORM-1）、钌（CORM-2和-3）、硼（CORM-A1）和铁（CORM-F3）的CO载体，以定制预防血管功能障碍、炎症、组织缺血和器官排斥的治疗方法。
