Department of Bio-medical Sciences, University of Catania, Catania, Italy.
Clin Exp Immunol. 2012 Feb;167(2):179-87. doi: 10.1111/j.1365-2249.2011.04491.x.
Carbon monoxide (CO) is produced during the catabolism of free haem, catalyzed by haem oxygenase (HO) enzymes, and its physiological roles include vasodilation, neurotransmission, inhibition of platelet aggregation and anti-proliferative effects on smooth muscle. In vivo preclinical studies have shown that exogenously administered quantities of CO may represent an effective treatment for conditions characterized by a dysregulated immune response. The carbon monoxide-releasing molecules (CORMs) represent a group of compounds capable of carrying and liberating controlled quantities of CO in the cellular systems. This review covers the physiological and anti-inflammatory properties of the HO/CO pathway in the central nervous system. It also discusses the effects of CORMs in preclinical models of inflammation. The accumulating data discussed herein support the possibility that CORMs may represent a novel class of drugs with disease-modifying properties in multiple sclerosis.
一氧化碳（CO）是在游离血红素的分解代谢过程中产生的，由血红素氧合酶（HO）酶催化，其生理作用包括血管扩张、神经递质传递、抑制血小板聚集和对平滑肌的抗增殖作用。体内临床前研究表明，外源性给予 CO 的量可能是治疗免疫反应失调特征的有效方法。一氧化碳释放分子（CORM）代表了一组能够在细胞系统中携带和释放受控量 CO 的化合物。这篇综述涵盖了中枢神经系统中 HO/CO 途径的生理和抗炎特性。它还讨论了 CORM 在炎症的临床前模型中的作用。本文讨论的累积数据支持了这样一种可能性，即 CORM 可能代表一类具有多发性硬化症疾病修饰特性的新型药物。
