一氧化碳在多发性硬化症中的治疗潜力。
Therapeutic potential of carbon monoxide in multiple sclerosis.
机构信息
Department of Bio-medical Sciences, University of Catania, Catania, Italy.
出版信息
Clin Exp Immunol. 2012 Feb;167(2):179-87. doi: 10.1111/j.1365-2249.2011.04491.x.
Abstract
Carbon monoxide (CO) is produced during the catabolism of free haem, catalyzed by haem oxygenase (HO) enzymes, and its physiological roles include vasodilation, neurotransmission, inhibition of platelet aggregation and anti-proliferative effects on smooth muscle. In vivo preclinical studies have shown that exogenously administered quantities of CO may represent an effective treatment for conditions characterized by a dysregulated immune response. The carbon monoxide-releasing molecules (CORMs) represent a group of compounds capable of carrying and liberating controlled quantities of CO in the cellular systems. This review covers the physiological and anti-inflammatory properties of the HO/CO pathway in the central nervous system. It also discusses the effects of CORMs in preclinical models of inflammation. The accumulating data discussed herein support the possibility that CORMs may represent a novel class of drugs with disease-modifying properties in multiple sclerosis.
摘要
一氧化碳（CO）是在游离血红素的分解代谢过程中产生的，由血红素氧合酶（HO）酶催化，其生理作用包括血管扩张、神经递质传递、抑制血小板聚集和对平滑肌的抗增殖作用。体内临床前研究表明，外源性给予 CO 的量可能是治疗免疫反应失调特征的有效方法。一氧化碳释放分子（CORM）代表了一组能够在细胞系统中携带和释放受控量 CO 的化合物。这篇综述涵盖了中枢神经系统中 HO/CO 途径的生理和抗炎特性。它还讨论了 CORM 在炎症的临床前模型中的作用。本文讨论的累积数据支持了这样一种可能性，即 CORM 可能代表一类具有多发性硬化症疾病修饰特性的新型药物。
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