Feigl Beatrix, Lovie-Kitchin Jan, Brown Brian
Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD, 4059, Australia.
Clin Exp Optom. 2005 Sep;88(5):304-12. doi: 10.1111/j.1444-0938.2005.tb06714.x.
This paper gives a brief review of methods that assess objectively function in age-related maculopathy (ARM) with emphasis on a newer method, the multifocal electroretinogram (mfERG). In contrast to other electrophysiological tests, such as the full-field and focal electroretinogram (ERG) or the electro-oculogram (EOG), which measure summed responses from various cells from larger areas of the retina, the multifocal electroretinogram maps function locally with a resolution as small as four degrees within the central 30 degrees. By using different paradigms it can measure local cone- and rod-mediated functional impairment at early and late stages of ARM. This improved mapping and higher resolution of the posterior pole compared to other objective methods might lead to earlier detection of ARM. Its usefulness has been demonstrated in documenting the effects of treatment after established laser treatments, such as photodynamic therapy (PDT) and in documenting function after retinal pigment epithelial transplantation, a possible future treatment in late neovascular ARM.
本文简要回顾了评估年龄相关性黄斑病变（ARM）客观功能的方法，重点介绍了一种较新的方法——多焦视网膜电图（mfERG）。与其他电生理测试不同，如全视野和焦点视网膜电图（ERG）或眼电图（EOG），它们测量的是来自视网膜较大区域各种细胞的总和反应，而多焦视网膜电图以局部方式绘制功能图，在中央30度范围内分辨率低至4度。通过使用不同的模式，它可以测量ARM早期和晚期局部视锥和视杆介导的功能损害。与其他客观方法相比，这种对后极更好的绘图和更高的分辨率可能会导致ARM的更早检测。其有用性已在记录既定激光治疗（如光动力疗法（PDT））后的治疗效果以及记录视网膜色素上皮移植后的功能方面得到证明，视网膜色素上皮移植是晚期新生血管性ARM未来可能的治疗方法。
