他汀类药物与主动脉瓣狭窄进展：生物靶点仍是一种选择吗？ - Suppr

Statins and aortic stenosis progression: are biologic targets still an option?

作者信息

Pai Ramdas G

机构信息

Division of Cardiology, Keck School of Medicine/University of Southern California, 1510 San Pablo Street, #322, Los Angeles, CA 90033, USA.

出版信息

Curr Cardiol Rep. 2005 Nov;7(6):399-400. doi: 10.1007/s11886-005-0055-x.

DOI:10.1007/s11886-005-0055-x

PMID:16256007

Abstract

摘要

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Statins and aortic stenosis progression: are biologic targets still an option?

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本文引用的文献

A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.

N Engl J Med. 2005 Jun 9;352(23):2389-97. doi: 10.1056/NEJMoa043876.

Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis.

Circulation. 2004 Sep 7;110(10):1291-5. doi: 10.1161/01.CIR.0000140723.15274.53. Epub 2004 Aug 30.

Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.

Circulation. 2003 Sep 30;108(13):1640-5. doi: 10.1161/01.CIR.0000087592.47401.37. Epub 2003 Sep 8.

Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.

Circulation. 2003 Aug 19;108(7):839-43. doi: 10.1161/01.CIR.0000084539.58092.DE. Epub 2003 Jul 28.

Attenuation of chronic hypoxic pulmonary hypertension by simvastatin.

Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H938-45. doi: 10.1152/ajpheart.01097.2002. Epub 2003 May 15.

Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.

Circulation. 2001 Oct 30;104(18):2205-9. doi: 10.1161/hc4301.098249.

Comparison of cardiovascular risk and lipid profiles in patients undergoing aortic valve surgery versus those undergoing coronary artery bypass grafting.

J Heart Valve Dis. 2001 Jan;10(1):19-24.

New insights into the progression of aortic stenosis: implications for secondary prevention.

Circulation. 2000 May 30;101(21):2497-502. doi: 10.1161/01.cir.101.21.2497.

Development and progression of aortic valve stenosis: atherosclerosis risk factors--a causal relationship? A clinical morphologic study.

Clin Cardiol. 1991 Dec;14(12):995-9. doi: 10.1002/clc.4960141210.

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Statins and aortic stenosis progression: are biologic targets still an option?

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