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他汀类药物对生物人工主动脉瓣退变进展的影响。

Effect of statins on the progression of bioprosthetic aortic valve degeneration.

作者信息

Antonini-Canterin Francesco, Zuppiroli Alfredo, Popescu Bogdan A, Granata Gianluca, Cervesato Eugenio, Piazza Rita, Pavan Daniela, Nicolosi Gian Luigi

机构信息

Unità Operativa di Cardiologia, A.R.C., Azienda Ospedaliera S. Maria degli Angeli, Pordenone, Italy.

出版信息

Am J Cardiol. 2003 Dec 15;92(12):1479-82. doi: 10.1016/j.amjcard.2003.08.066.

DOI:10.1016/j.amjcard.2003.08.066
PMID:14675593
Abstract

To date, there is no proved medical therapy able to significantly reduce the degenerative process of biologic prosthetic aortic valves. It has recently been suggested that statins may reduce the progression of native aortic valve stenosis. We examined the effect of statin treatment on bioprosthetic aortic valve degeneration and found a beneficial effect of statins in slowing bioprosthetic degeneration.

摘要

迄今为止,尚无经证实的医学疗法能够显著减缓生物人工主动脉瓣的退变过程。最近有研究表明,他汀类药物可能会减缓天然主动脉瓣狭窄的进展。我们研究了他汀类药物治疗对生物人工主动脉瓣退变的影响,发现他汀类药物在减缓生物人工瓣膜退变方面具有有益作用。

相似文献

1
Effect of statins on the progression of bioprosthetic aortic valve degeneration.他汀类药物对生物人工主动脉瓣退变进展的影响。
Am J Cardiol. 2003 Dec 15;92(12):1479-82. doi: 10.1016/j.amjcard.2003.08.066.
2
Statins and aortic stenosis progression: are biologic targets still an option?他汀类药物与主动脉瓣狭窄进展:生物靶点仍是一种选择吗?
Curr Cardiol Rep. 2005 Nov;7(6):399-400. doi: 10.1007/s11886-005-0055-x.
3
Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.羟甲基戊二酰辅酶A还原酶抑制剂对钙化性主动脉瓣狭窄进展的影响。
Circulation. 2001 Oct 30;104(18):2205-9. doi: 10.1161/hc4301.098249.
4
Do statins slow the process of calcification of aortic tissue valves?他汀类药物能减缓主动脉组织瓣膜的钙化进程吗?
Interact Cardiovasc Thorac Surg. 2010 Sep;11(3):297-301. doi: 10.1510/icvts.2009.230920. Epub 2010 Jun 22.
5
Metabolic syndrome is associated with faster degeneration of bioprosthetic valves.代谢综合征与生物瓣膜更快的退变相关。
Circulation. 2006 Jul 4;114(1 Suppl):I512-7. doi: 10.1161/CIRCULATIONAHA.105.000422.
6
Statins may not prevent structural valve degeneration of aortic bioprosthetic valves, but should probably be prescribed to patients undergoing heart valve surgery nonetheless.他汀类药物可能无法预防主动脉生物瓣膜的结构瓣膜退变,但尽管如此,仍可能应给接受心脏瓣膜手术的患者开此类药物。
Interact Cardiovasc Thorac Surg. 2010 Sep;11(3):302. doi: 10.1510/icvts.2009.230920B.
7
Degeneration of native and tissue prosthetic valve in aortic position: do statins play an effective role in prevention?主动脉位置的天然瓣膜和人工组织瓣膜退变:他汀类药物在预防中是否发挥有效作用?
Int J Cardiol. 2007 Mar 20;116(2):144-52. doi: 10.1016/j.ijcard.2006.03.047. Epub 2006 Jul 10.
8
Detection and Prediction of Bioprosthetic Aortic Valve Degeneration.生物瓣主动脉瓣退化的检测与预测。
J Am Coll Cardiol. 2019 Mar 19;73(10):1107-1119. doi: 10.1016/j.jacc.2018.12.056.
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Atorvastatin therapy is not associated with slowing the progression of aortic stenosis: findings of a randomized controlled trial.阿托伐他汀治疗与延缓主动脉瓣狭窄进展无关:一项随机对照试验的结果
Clin Lab. 2013;59(3-4):299-305. doi: 10.7754/clin.lab.2012.120319.
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Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg).无症状主动脉瓣狭窄患者的预后及危险因素,以及阿托伐他汀(20毫克)对其的调节作用
Am J Cardiol. 2008 Sep 15;102(6):743-8. doi: 10.1016/j.amjcard.2008.04.060. Epub 2008 Jul 2.

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Medium-term survival of patients with mechanical and biological aortic prosthesis at the 6th decade of life.第六个十年患有机械和生物主动脉假体的患者的中期生存情况。
PLoS One. 2024 Nov 18;19(11):e0312408. doi: 10.1371/journal.pone.0312408. eCollection 2024.
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Association between remnant cholesterol and progression of bioprosthetic valve degeneration.
残余胆固醇与生物瓣退行性变进展的关系。
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Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification.生物人工心脏瓣膜钙化的机制与药物治疗
Front Pharmacol. 2022 Jun 3;13:909801. doi: 10.3389/fphar.2022.909801. eCollection 2022.
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Degeneration of Bioprosthetic Heart Valves: Update 2020.生物瓣心脏瓣膜的退行性变:2020 年更新。
J Am Heart Assoc. 2020 Oct 20;9(19):e018506. doi: 10.1161/JAHA.120.018506. Epub 2020 Sep 21.
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Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves.糖基化和血清白蛋白浸润导致生物人工心脏瓣膜结构退变。
JACC Basic Transl Sci. 2020 Aug 5;5(8):755-766. doi: 10.1016/j.jacbts.2020.06.008. eCollection 2020 Aug.
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Anatomical and functional changes after aortic valve replacement with different sizes of mechanical valves.不同尺寸机械瓣膜置换主动脉瓣后的解剖学和功能变化。
Cardiovasc J Afr. 2018;29(6):338-343. doi: 10.5830/CVJA-2018-037. Epub 2018 Jul 17.
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World J Cardiol. 2017 Aug 26;9(8):667-672. doi: 10.4330/wjc.v9.i8.667.
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Differing relationship between hypercholesterolemia and a bicuspid aortic valve according to the presence of aortic valve stenosis or aortic valve regurgitation.根据主动脉瓣狭窄或主动脉瓣反流的存在情况,高胆固醇血症与二叶式主动脉瓣之间存在不同的关系。
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