Roth M
Radiodiagnostic Clinic, Medical Faculty Hospital, Masaryk University, Brno, Czechoslovakia.
Med Hypotheses. 1992 Apr;37(4):259-67. doi: 10.1016/0306-9877(92)90198-l.
Some common morphological and functional features of the sperm and of the neuroblast (above all the resistance of the egg once fertilized to penetration of further sperms and of the embryonic cell once innervated to additional innervation) point to their developmental relationship, viz. to continued existence of the sperm, following temporary disappearance and genetic interaction within the egg, in the form of a neuroblast. The egg and the sperm would thus give origin to the two basic growth types of the vertebrate body, viz. the cellular-divisional (of the non-nervous tissues) related to the egg and the neural-extensive originating in the sperm and characterized by sprouting of processes even several decimeters long from a single nerve cell body. The nervous system, in addition to its intricate functions, represents an extremely dense feltwork of nervous trunks, branches and fibres, the 'nervous skeleton' (6), the product of the extensive neural growth which is 'stuffed' with the products of the cellular divisional proliferation of the other, non-nervous tissues. The absence of nerves (or of normal nerves) within the malignant tumours points to cellular 'escape' from the limiting confines of the nervous skeleton as the biological cause of malignancy: the 'escaped' cells pursue the one-growth type way of life instead of the normal two-growth-types way, viz. they revert back towards the egg-condition and acquire embryonic features. Introduction of neuroblasts into the malignant tumour aimed at re-establishment of its nervous skeleton should convert the malignant lesion into a benign one.
精子和神经母细胞的一些常见形态和功能特征（最重要的是，受精后的卵子对其他精子穿透的抵抗力，以及受神经支配后的胚胎细胞对额外神经支配的抵抗力）表明了它们之间的发育关系，即精子在卵子内暂时消失并发生基因相互作用后，以神经母细胞的形式持续存在。因此，卵子和精子将产生脊椎动物身体的两种基本生长类型，即与卵子相关的细胞分裂型（非神经组织的）和起源于精子的神经扩展型，其特征是从单个神经细胞体长出甚至长达数分米的突起。神经系统除了其复杂的功能外，还代表着一个由神经干、分支和纤维组成的极其密集的网络，即“神经骨架”（6），它是广泛神经生长的产物，其中“填充”着其他非神经组织的细胞分裂增殖产物。恶性肿瘤内神经（或正常神经）的缺失表明细胞从神经骨架的限制范围内“逃逸”是恶性肿瘤的生物学原因：“逃逸”的细胞采用单一生长类型的生活方式，而不是正常的两种生长类型的方式，即它们恢复到卵子状态并获得胚胎特征。将神经母细胞引入恶性肿瘤以重建其神经骨架，应能将恶性病变转化为良性病变。
