Beilin Y, Arnold I, Hossain S
Department of Anesthesiology, Mount Sinai School of Medicine of New York University, New York, NY 10029-6574, USA.
Int J Obstet Anesth. 2006 Jan;15(1):7-12. doi: 10.1016/j.ijoa.2005.04.013. Epub 2005 Oct 26.
The platelet function analyzer (PFA-100) is a bedside test of coagulation designed to evaluate platelet function. It measures the time required for whole blood to occlude a membrane impregnated with either epinephrine (EPI) or adenosine 5'diphosphate (ADP). The results are reported as closure time (CT-EPI or CT-ADP) in seconds. The thromboelastogram (TEG) measures whole blood clotting and the maximum amplitude (MA) correlates with platelet count and function. We wished to establish whether there is a correlation between the CT and platelet count, between the CT and MA, and between the MA and platelet count.
Platelet count, CT, and MA were measured in blood drawn from 172 healthy term parturients using the PFA-100.
We were unable to detect a significant correlation between the CT-EPI and platelet count (r=-0.1, P=0.21), or the CT-ADP and platelet count (r=-0.02, P=0.83). We also did not find a correlation between the CT-EPI and MA (r=-0.13, P=0.12) or between the CT-ADP and MA (r=-0.11, P=0.19). However, we found a significant correlation between platelet count and MA (r=0.33, P<0.001).
We conclude that the CT does not correlate with the platelet count or MA in the parturient, but the TEG does. Therefore the TEG may be a better tool to evaluate coagulation in the parturient with thrombocytopenia.
血小板功能分析仪（PFA - 100）是一种用于评估血小板功能的床旁凝血检测方法。它测量全血阻塞浸渍有肾上腺素（EPI）或5'-二磷酸腺苷（ADP）的膜所需的时间。结果以秒为单位报告为封闭时间（CT - EPI或CT - ADP）。血栓弹力图（TEG）测量全血凝血，最大振幅（MA）与血小板计数和功能相关。我们希望确定CT与血小板计数之间、CT与MA之间以及MA与血小板计数之间是否存在相关性。
使用PFA - 100对172名健康足月产妇采集的血液进行血小板计数、CT和MA测量。
我们未能检测到CT - EPI与血小板计数之间存在显著相关性（r = -0.1，P = 0.21），或CT - ADP与血小板计数之间存在显著相关性（r = -0.02，P = 0.83）。我们也未发现CT - EPI与MA之间存在相关性（r = -0.13，P = 0.12）或CT - ADP与MA之间存在相关性（r = -0.11，P = 0.19）。然而，我们发现血小板计数与MA之间存在显著相关性（r = 0.33，P < 0.001）。
我们得出结论，在产妇中，CT与血小板计数或MA不相关，但TEG相关。因此，TEG可能是评估血小板减少症产妇凝血功能的更好工具。
