一种基于融合基因的DNA HIV-1疫苗，该融合基因表达A-C亚型共识序列以及F-H亚型祖先序列的非结构和结构基因。临床前和临床研究。
A DNA HIV-1 vaccine based on a fusion gene expressing non-structural and structural genes of consensus sequence of the A-C subtypes and the ancestor sequence of the F-H subtypes. Preclinical and clinical studies.
作者信息
Krohn Kai, Stanescu Ioana, Blazevic Vesna, Vesikari Timo, Ranki Annamari, Ustav Mart
机构信息
Institute of Medical Technology, University of Tampere, Biokatu 8, 33520 Tampere, Finland.
出版信息
Microbes Infect. 2005 Nov;7(14):1405-13. doi: 10.1016/j.micinf.2005.07.023. Epub 2005 Oct 4.
PMID:16257560
Abstract
A potent DNA vaccine against HIV, combining a vector that takes advantage of the segregation and compartmentalization effect of bovine papilloma virus E2 protein with MultiHIV insert, expressing a fusion gene coding for the non-structural and structural proteins was developed and tested for immunogenicity in mice and humans.
摘要
一种针对HIV的高效DNA疫苗被研发出来，并在小鼠和人类身上测试了其免疫原性。该疫苗结合了一种利用牛乳头瘤病毒E2蛋白的分离和区室化效应的载体与MultiHIV插入片段，表达一种编码非结构蛋白和结构蛋白的融合基因。
Zotero 插件