González Burchard Esteban, Borrell Luisa N, Choudhry Shweta, Naqvi Mariam, Tsai Hui-Ju, Rodriguez-Santana Jose R, Chapela Rocio, Rogers Scott D, Mei Rui, Rodriguez-Cintron William, Arena Jose F, Kittles Rick, Perez-Stable Eliseo J, Ziv Elad, Risch Neil
Department of Medicine, University of California, San Francisco, CA 94143-0833, USA.
Am J Public Health. 2005 Dec;95(12):2161-8. doi: 10.2105/AJPH.2005.068668. Epub 2005 Oct 27.
Latinos are the largest minority population in the United States. Although usually classified as a single ethnic group by researchers, Latinos are heterogeneous from cultural, socioeconomic, and genetic perspectives. From a cultural and social perspective, Latinos represent a wide variety of national origins and ethnic and cultural groups, with a full spectrum of social class. From a genetic perspective, Latinos are descended from indigenous American, European, and African populations. We review the historical events that led to the formation of contemporary Latino populations and use results from recent genetic and clinical studies to illustrate the unique opportunity Latino groups offer for studying the interaction between racial, genetic, and environmental contributions to disease occurrence and drug response.
拉丁裔是美国最大的少数族裔群体。尽管研究人员通常将其归为单一族群，但从文化、社会经济和基因角度来看，拉丁裔是异质的。从文化和社会角度而言，拉丁裔代表了各种各样的祖籍以及族裔和文化群体，涵盖了整个社会阶层。从基因角度来看，拉丁裔是美洲原住民、欧洲人和非洲人的后裔。我们回顾了导致当代拉丁裔群体形成的历史事件，并利用近期基因和临床研究的结果来说明拉丁裔群体为研究种族、基因和环境因素对疾病发生及药物反应的相互作用所提供的独特机会。
