西班牙裔/拉丁裔成年人中宗教、灵性与下丘脑-垂体-肾上腺（HPA）轴基因的DNA甲基化
Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.
作者信息
Zhen-Duan Jenny, Canenguez Katia M, Wilson Anna E, Gu Yue, Valluri Harshitha G, Chavez Alejandra D, Argentieri M Austin, Schachter Anna Boonin, Wu Haotian, Baccarelli Andrea A, Daviglus Martha L, Wassertheil-Smoller Sylvia, Warner Erica T, Shields Alexandra E
机构信息
Disparities Research Unit, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
出版信息
Epigenomics. 2025 Feb;17(3):155-166. doi: 10.1080/17501911.2024.2442293. Epub 2024 Dec 20.
AIM
Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.
METHODS
We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.
RESULTS
Among individuals with the CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased (CC genotype) methylation among immigrants.
CONCLUSION
R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.
目的
在西班牙裔社区健康研究/拉丁裔队列研究的992名成年人中，调查宗教与灵性（R&S）与四个下丘脑-垂体-肾上腺轴（HPA轴）基因（即14个CpG位点）的DNA甲基化之间的关联。
方法
我们评估了1）R&S测量值与总体平均甲基化百分比之间的关联，并按出生状态（美国出生或移民）进行分层，以及2）R&S与甲基化之间的相互作用是否因出生状态而异。
结果
在具有CC基因型的个体中，与美国出生的参与者相比，灵性得分增加与移民中显著较低的甲基化水平相关。组织性宗教活动（如参加宗教仪式）与移民中（CC基因型）甲基化增加相关。
结论
R&S可能根据出生状态对HPA轴功能产生不同影响；这一发现可能有助于深入了解导致健康差异的机制。
Zotero 插件