碱性成纤维细胞生长因子（bFGF）在大鼠大脑中发挥核心作用，抑制胃排空。

Basic fibroblast growth factor (bFGF) acts centrally in the brain to inhibit gastric emptying in rats.

作者信息

Okumura T, Uehara A, Kitamori S, Watanabe Y, Taniguchi Y, Tsuji K, Namiki M

机构信息

Department of Internal Medicine III, Asahikawa Medical College, Hokkaido, Japan.

出版信息

Neurosci Lett. 1992 Mar 16;137(1):53-5. doi: 10.1016/0304-3940(92)90296-j.

DOI:10.1016/0304-3940(92)90296-j

PMID:1625818

Abstract

In the present study, we evaluated the central nervous system action of basic fibroblast growth factor (bFGF) on gastric emptying of a liquid meal in conscious rats using a Phenol red method. Intracisternal injection of bFGF dose-dependently inhibited gastric emptying, while intraperitoneal injection of bFGF at the same doses failed to alter gastric emptying. These results suggest for the first time that bFGF acts in the central nervous system to delay gastric emptying.

摘要

在本研究中，我们使用酚红法评估了碱性成纤维细胞生长因子（bFGF）对清醒大鼠液体餐胃排空的中枢神经系统作用。脑池内注射bFGF剂量依赖性地抑制胃排空，而相同剂量腹腔内注射bFGF未能改变胃排空。这些结果首次表明bFGF在中枢神经系统中发挥作用以延迟胃排空。