碱性成纤维细胞生长因子的中枢神经系统作用：抑制胃酸和胃蛋白酶分泌。

Central nervous system action of basic fibroblast growth factor: inhibition of gastric acid and pepsin secretion.

作者信息

Okumura T, Uehara A, Tsuji K, Taniguchi Y, Kitamori S, Shibata Y, Okamura K, Takasugi Y, Namiki M

机构信息

Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.

出版信息

Biochem Biophys Res Commun. 1991 Mar 15;175(2):527-31. doi: 10.1016/0006-291x(91)91596-5.

DOI:10.1016/0006-291x(91)91596-5

PMID:2018501

Abstract

To examine the effects of basic fibroblast growth factor (bFGF) on gastric secretion, the present study was carried out using pylorus-ligated rats. Intracisternally injected bFGF inhibited the secretion of both gastric acid and pepsin, and this gastric antisecretory action of bFGF was a dose-related response. On the other hand, the intraperitoneal injection of bFGF did not change gastric secretion. These results strongly suggested for the first time that bFGF, a growth factor that promotes the proliferation of various cell types, might also be a chemical messenger that is involved in the central regulation of gastric secretion. This biological action of bFGF may be considered as a novel nonmitogenic activity of this growth factor.

摘要

为研究碱性成纤维细胞生长因子（bFGF）对胃酸分泌的影响，本研究采用幽门结扎大鼠进行。脑池内注射bFGF可抑制胃酸和胃蛋白酶的分泌，且bFGF的这种胃抗分泌作用呈剂量相关反应。另一方面，腹腔注射bFGF对胃酸分泌无影响。这些结果首次有力地表明，bFGF作为一种促进多种细胞类型增殖的生长因子，可能也是参与胃酸分泌中枢调节的化学信使。bFGF的这种生物学作用可被视为该生长因子一种新的非促有丝分裂活性。