Wahlström G, Archer T, Lärkfors L
Department of Pharmacology, University of Umeå, Sweden.
Neurosci Lett. 1992 Mar 16;137(1):65-8. doi: 10.1016/0304-3940(92)90299-m.
Nerve growth factor (NGF) protein has been implicated in alterations of cognitive function either following brain damage, selective lesions or aging. Groups of rats were given long-term (48 weeks) oral barbital treatment or tap water and following an extended period of abstinence (14 weeks) were tested for spatial learning ability in the Morris swim maze. Following the maze test, they were sacrificed and the NGF content of hippocampal and cortical brain regions were analyzed. Barbital treated rats were divided into convulsing and non-convulsing groups. It was found that there was a slight, significant increase (12%) in NGF content of the hippocampus in convulsing rats. Correlations between maze learning performance, brain weight and NGF in the cortex indicated a significant negative relationship between (a) performance and brain weight on day 1 of testing and (b) NGF content and performance on day 2. These data indicate some involvement of NGF in functions derived from a considerably different animal model to those applied previously.
神经生长因子（NGF）蛋白与脑损伤、选择性损伤或衰老后认知功能的改变有关。将大鼠分组，一组给予长期（48周）口服巴比妥治疗，另一组给予自来水，经过较长时间的戒断期（14周）后，在莫里斯水迷宫中测试其空间学习能力。迷宫测试后，将它们处死并分析海马和皮质脑区的NGF含量。接受巴比妥治疗的大鼠分为惊厥组和非惊厥组。结果发现，惊厥大鼠海马中的NGF含量略有显著增加（12%）。迷宫学习表现、脑重量和皮质中NGF之间的相关性表明：（a）测试第一天的表现与脑重量之间以及（b）第二天的NGF含量与表现之间存在显著的负相关。这些数据表明，NGF参与了一种与先前应用的动物模型有很大不同的功能。
