Fiorot Júnior José Antonio, Felício André Carvalho, Fukujima Márcia Mauimi, Rodrigues Celso Arraes, Morelli Vânia Maria, Lourenço Dayse Maria, Prado Gilmar Fernandes do
Division of Neurology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2005 Sep;63(3B):852-4. doi: 10.1590/s0004-282x2005000500025. Epub 2005 Oct 18.
Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations. We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced an infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombin gene increase the risk of CVT.
几种感染性病因与脑静脉血栓形成（CVT）有关，但文献回顾显示与结核病（TB）相关的病例很少，仅有一例有神经学表现。我们报告一例与TB及凝血酶原基因突变相关的不寻常CVT病例。一名38岁黑人男性突然出现右侧半身感觉异常和偏瘫。检查发现为CVT。脑脊液（CSF）检查证实有分枝杆菌感染。他是凝血酶原G20210A突变的杂合子。可能是TB的高凝机制，加上凝血酶原基因的突变增加了CVT的风险。
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