Shin Jung-Wook, Sue Ju-Hee, Song Tae-Won, Kim Kyung-Won, Kim Eun-Soo, Sohn Myung Hyun, Kim Kyu-Earn
Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Science, Biomolecule Secretion Research Center, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun- gu, Seoul 120-752, Korea.
Yonsei Med J. 2005 Oct 31;46(5):629-34. doi: 10.3349/ymj.2005.46.5.629.
Asthma is commonly described as an atopic disease in childhood, but some cases of this disorder do not fit this description. The aim of this study was to evaluate the frequency of atopy, asthma, and sensitization to house dust mites in children with allergic symptoms. This study was performed at the Severance Hospital of Yonsei University with patients who visited the allergy clinic for evaluation of nonspecific upper respiratory symptoms, typical symptoms of asthma, or a general health workup. The patients were divided into three age groups: 0-3 years (group 1), 4-7 years (group 2), and 8-12 years (group 3). Of the 1,244 children examined, 844 (67.8%) were atopic and 400 (32.2%) were non-atopic. The frequency of atopy and asthma increased with age. Asthma was diagnosed in the same proportion (64%) of atopic and non-atopic children. As risk factors for asthma symptoms, the positive values of house dust mite (HDM) sensitivity were significantly increased in groups 1, 2, and 3 to 53.5%, 68.9%, and 80.2%, respectively. A significant difference between the percentage of asthmatics sensitized to HDM and that of asthmatics not sensitized to HDM was found only in group 3. In conclusion, asthma is related to atopy with increasing age, and house dust mite sensitization seems to be an important determinant of asthma in older children in Korea.
哮喘通常被描述为儿童期的一种特应性疾病，但该疾病的一些病例并不符合这一描述。本研究的目的是评估有过敏症状儿童的特应性、哮喘以及对屋尘螨致敏的频率。本研究在延世大学Severance医院对因非特异性上呼吸道症状、典型哮喘症状或一般健康检查而前往过敏门诊就诊的患者进行。患者被分为三个年龄组：0 - 3岁（第1组）、4 - 7岁（第2组）和8 - 12岁（第3组）。在1244名接受检查的儿童中，844名（67.8%）为特应性，400名（32.2%）为非特应性。特应性和哮喘的频率随年龄增加而升高。特应性和非特应性儿童中哮喘的诊断比例相同（64%）。作为哮喘症状的危险因素，第1组、第2组和第3组屋尘螨（HDM）敏感性阳性值分别显著升高至53.5%、68.9%和80.2%。仅在第3组中发现对HDM致敏的哮喘患者百分比与未对HDM致敏的哮喘患者百分比之间存在显著差异。总之，哮喘与年龄增长相关的特应性有关，屋尘螨致敏似乎是韩国大龄儿童哮喘的一个重要决定因素。
