Mikaelian N P
Patol Fiziol Eksp Ter. 1992 Jan-Feb(1):19-21.
Study of the effect of the crush syndrome on cell metabolism and insulin-binding activity revealed a new aspect of the pathogenesis of the syndrome, namely, a marked reaction of the mononuclear receptor apparatus. Accumulation of lactate in the tissues and the development of acidosis probably play an important role in disturbance of the insulin-binding activity of the plasma membrane. Reduction of the level of tree adenine nucleotides and ATP in particular may be of essential importance in the late stages of compression. Of importance in the pathogenesis of the crush syndrome was the binding of insulin with its receptors and the subsequent intensification of metabolic disorders and reduction of phosphorylation, which in turn may be the cause of reduced transmission of the signal to the receptors, i. e. disorder of the postreceptor action of insulin.
挤压综合征对细胞代谢及胰岛素结合活性影响的研究揭示了该综合征发病机制的一个新方面，即单核受体装置的显著反应。组织中乳酸的蓄积及酸中毒的发展可能在质膜胰岛素结合活性紊乱中起重要作用。尤其是游离腺嘌呤核苷酸及ATP水平的降低在挤压后期可能至关重要。胰岛素与其受体的结合以及随后代谢紊乱的加剧和磷酸化的减少在挤压综合征发病机制中具有重要意义，而这反过来可能是信号向受体传递减少的原因，即胰岛素受体后作用紊乱。
