Chernin V V, Bazlov S N, Chervinets V M
Eksp Klin Gastroenterol. 2004(6):58-62, 164.
The studies that were conducted for 82 patients with ulcer established that 22 genera of microorganisms including H. pylori in a combination from 2 up to 8 various microbial cultures can be secured from the biopsy of the mucous coat of the pre-ulcer zone at the acute phase of recurrence. They have high enzymatic and cytotoxic activity. This draws together microbiological characteristics of the ulcer defect with parameters of the infected wound and corresponds to dysbacteriosis of the third degree. The data obtained form the basis for considering that the exacerbation of ulcer is accompanied by expressed dysbiotic shifts depending on the recurrence phase. It is necessary for taking this into account in the development of methods of adequate therapy for the disease aimed at the suppression of the excess growth of mucous microflora and restoration of normal microbiocenosis in the gastroduodenal zone.
对82例溃疡患者进行的研究表明，在复发急性期，从溃疡前期区域黏膜活检中可检出包括幽门螺杆菌在内的22个微生物属，它们以2至8种不同微生物培养物的组合形式存在。它们具有高酶活性和细胞毒性活性。这将溃疡缺损的微生物学特征与感染伤口的参数联系在一起，符合三度菌群失调。所获得的数据构成了以下观点的依据，即溃疡的加重伴随着取决于复发阶段的明显的生态失调变化。在开发针对该疾病的适当治疗方法时，有必要考虑到这一点，这些方法旨在抑制黏膜微生物过度生长并恢复胃十二指肠区域的正常微生物群落。
