Rasmussen Svein, Bergsjø Per, Jacobsen Geir, Haram Kjell, Bakketeig Leiv S
Department of Clinical Medicine, Section of Obstetrics and Gynecology, University of Bergen, Bergen, Norway.
Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):27-34. doi: 10.1016/j.ejogrb.2005.02.012.
Little is known about factors which may influence haemoglobin (Hb) and ferritin levels in pregnancy.
To analyse if haemoglobin and ferritin levels during pregnancy are influenced by maternal age, body mass index, cigarette smoking, and iron supplementation.
A random sample of 561 parous pregnant women were recruited from the catchment areas of three Scandinavian university hospitals. The analyses were based on 5024 haemoglobin and 1529 ferritin measures sampled from the first trimester to 42 weeks of gestation. Multilevel modelling was used to construct mean and percentile curves for haemoglobin and ferritin by gestational age.
Women aged 25-34 years had significantly higher haemoglobin values than older and younger women. Haemoglobin values were significantly lower for women with body mass index < 19 kg/m(2) than for women with body mass index > or =19. Smokers had significantly lower haemoglobin values throughout pregnancy compared to non-smokers, with the lowest values among women who smoked 1-9 cigarettes per day. There were no similar associations between ferritin and maternal age, body mass index, or smoking. Women with iron supplementation throughout pregnancy had a higher relative increase in haemoglobin concentration toward the end of pregnancy. In non-supplemented women the decline in ferritin concentration was significantly steeper than in those who received iron supplementation.
Haemoglobin levels during pregnancy are significantly associated with maternal age, cigarette smoking, body mass index, and iron supplementation. No such associations were found with ferritin levels, except for iron supplementation.
关于孕期可能影响血红蛋白（Hb）和铁蛋白水平的因素，人们了解甚少。
分析孕期血红蛋白和铁蛋白水平是否受产妇年龄、体重指数、吸烟及铁补充剂的影响。
从三家斯堪的纳维亚大学医院的服务区域随机抽取561名经产妇作为研究对象。分析基于从妊娠早期到妊娠42周期间采集的5024份血红蛋白和1529份铁蛋白测量值。采用多水平模型构建按孕周划分的血红蛋白和铁蛋白的均值曲线及百分位数曲线。
25至34岁的女性血红蛋白值显著高于年龄较大和较小的女性。体重指数<19kg/m²的女性血红蛋白值显著低于体重指数≥19的女性。与不吸烟者相比，吸烟者在整个孕期的血红蛋白值显著较低，每天吸1至9支烟的女性血红蛋白值最低。铁蛋白与产妇年龄、体重指数或吸烟之间不存在类似关联。整个孕期补充铁剂的女性在妊娠末期血红蛋白浓度的相对增幅更高。在未补充铁剂的女性中，铁蛋白浓度的下降幅度明显大于补充铁剂的女性。
孕期血红蛋白水平与产妇年龄、吸烟、体重指数及铁补充剂显著相关，但铁蛋白水平除与铁补充剂有关外，未发现此类关联。
