Kaneshige E
Obstet Gynecol. 1981 Feb;57(2):238-42.
Serum ferritin concentration has been thought to be a useful index of the status of iron stores. Serum ferritin concentration and hemoglobin, serum iron, and transferrin levels were measured simultaneously. In first-trimester pregnant women, serum iron and ferritin levels increased significantly as compared with those in nonpregnant women. During the second and third trimesters, serum iron and ferritin levels decreased significantly. However, hemoglobin levels showed little change and transferrin levels increased. At delivery, serum iron levels in cord blood were about twice as high as those in maternal blood, and serum ferritin levels in cord blood were about 10 times higher than those in maternal blood. Serum iron and ferritin levels between maternal and cord blood were well correlated. These results suggest that maternal body iron storage is depleted during the second trimester in patients who are not receiving supplemental iron. The data are also consistent with the concept that maternal serum iron is transported across the placenta by active transport and that a deficiency of maternal iron storage results in a deficiency of neonatal iron storage.
血清铁蛋白浓度一直被认为是铁储备状况的一个有用指标。同时测定了血清铁蛋白浓度、血红蛋白、血清铁和转铁蛋白水平。在孕早期孕妇中，与非孕妇相比，血清铁和铁蛋白水平显著升高。在孕中期和孕晚期，血清铁和铁蛋白水平显著下降。然而，血红蛋白水平变化不大，转铁蛋白水平升高。分娩时，脐血中的血清铁水平约为母血的两倍，脐血中的血清铁蛋白水平约为母血的10倍。母血和脐血之间的血清铁和铁蛋白水平相关性良好。这些结果表明，在未补充铁剂的患者中，孕中期母体的铁储备会耗尽。这些数据也与以下概念一致，即母体血清铁通过主动转运穿过胎盘，母体铁储备不足会导致新生儿铁储备不足。
