Harley J B, Scofield R H, Reichlin M
University of Oklahoma Health Sciences Center, Oklahoma City.
Rheum Dis Clin North Am. 1992 May;18(2):337-58.
Anti-Ro autoantibodies are frequently found in the sera of patients with Sjögren's syndrome, systemic lupus erythematosus, and subacute cutaneous lupus erythematosus as well as in the sera of mothers of infants with the neonatal lupus syndrome. Close associations have been found between anti-Ro and a number of clinical manifestations, particularly including hematologic cytopenias, heart block, and photosensitive skin rashes. Serologic and genetic associations have been found between anti-Ro and anti-La, rheumatoid factor, hypergammaglobulinemia, the histocompatibility alleles DQ1 and DQ2, and alleles of the T-cell receptor beta chain gene. The origin of anti-Ro and other autoantigens is thought to relate to the etiology of Sjögren's syndrome and systemic lupus erythematosus and remains the most fundamental unanswered question preventing a comprehensive understanding of these diseases.
抗Ro自身抗体常见于干燥综合征、系统性红斑狼疮和亚急性皮肤型红斑狼疮患者的血清中，也见于新生儿狼疮综合征患儿母亲的血清中。抗Ro与多种临床表现密切相关，尤其是血细胞减少、心脏传导阻滞和光敏性皮疹。已发现抗Ro与抗La、类风湿因子、高球蛋白血症、组织相容性等位基因DQ1和DQ2以及T细胞受体β链基因的等位基因之间存在血清学和遗传学关联。抗Ro及其他自身抗原的起源被认为与干燥综合征和系统性红斑狼疮的病因有关，仍然是阻碍全面理解这些疾病的最基本的未解决问题。
