Department of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Anhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu, 233003, China.
Sci Rep. 2023 Jun 21;13(1):10101. doi: 10.1038/s41598-023-37100-5.
To study the clinical significance of autoantibodies in Chinese patients with new-onset systemic lupus erythematosus (SLE), we enrolled 526 new-onset patients who met the 1997 Updated American College of Rheumatology SLE Classification Criteria for a retrospective cohort study. Chi-square test and Wilcoxon rank-sum test were used to detect the relationship of autoantibodies with clinical manifestations and serological results respectively. Our results demonstrated that the positive rate of anti-ribosomal P protein (anti-P) antibody in female patients was higher than that in male patients (41.2% vs. 22%, P = 0.008). Patients with anti-SSB (43.95 ± 73.12 vs. 40.92 ± 75.75, P = 0.004; 63.93 ± 103.56 vs. 55.06 ± 120.84, P = 0.008 respectively) antibodies had higher levels of alanine aminotransferase (ALT) and aspartate transaminase (AST), whereas those with anti-P antibody (28.90 ± 25.70 vs. 50.08 ± 93.00, P = 0.014; 38.51 ± 48.19 vs. 69.95 ± 142.67, P = 0.047, respectively) had lower levels of them. Anti-dsDNA antibody (P = 0.021) was associated with pulmonary arterial hypertension (PAH). The patients with anti-Ro60 (P = 0.044), anti-P (P = 0.012) and anti-dsDNA (P = 0.013) antibodies were less likely to develop Interstitial lung disease. Anti-SmRNP antibody was correlated to lower prevalence of neuropsychiatric symptoms (P = 0.037), and patients with anti-centromere antibody (ACA) were more likely to develop serositis (P = 0.016).We identified five clusters of SLE-related autoantibodies, confirmed previously reported associations of autoantibodies, and discovered new associations.
为了研究中国新诊断系统性红斑狼疮（SLE）患者自身抗体的临床意义，我们纳入了 526 例符合 1997 年美国风湿病学会（ACR）修订的 SLE 分类标准的新诊断患者进行回顾性队列研究。卡方检验和 Wilcoxon 秩和检验分别用于检测自身抗体与临床表现和血清学结果之间的关系。我们的结果表明，女性患者抗核糖体 P 蛋白（anti-P）抗体的阳性率高于男性患者（41.2%比 22%，P=0.008）。抗 SSB 抗体（43.95±73.12 比 40.92±75.75，P=0.004；63.93±103.56 比 55.06±120.84，P=0.008）阳性的患者丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转移酶（AST）水平较高，而抗 P 抗体（28.90±25.70 比 50.08±93.00，P=0.014；38.51±48.19 比 69.95±142.67，P=0.047）阳性的患者这两种酶的水平较低。抗双链 DNA（dsDNA）抗体（P=0.021）与肺动脉高压（PAH）相关。抗 Ro60（P=0.044）、抗 P（P=0.012）和抗 dsDNA（P=0.013）抗体阳性的患者发生间质性肺病的可能性较小。抗 SmRNP 抗体与神经精神症状的发生率较低相关（P=0.037），而抗着丝点抗体（ACA）阳性的患者更易发生浆膜炎（P=0.016）。我们鉴定了 5 个与 SLE 相关的自身抗体簇，证实了先前报道的自身抗体之间的关联，并发现了新的关联。
