Bachelez Hervé
Department of Dermatology 1 and Unité INSERM U697, Hôpital Saint-Louis, Paris, France.
J Autoimmun. 2005;25 Suppl:69-73. doi: 10.1016/j.jaut.2005.09.025. Epub 2005 Nov 2.
Psoriasis is a frequent chronic inflammatory disorder involving mostly skin and joints. Its characteristic features in the skin consist of inflammatory changes in both dermis and epidermis, with abnormal keratinocytic differentiation and proliferation. In recent years, an important set of knowledge has been provided by works addressing the immunopathogenic mechanisms of the disease. Indeed, recent advances in the knowledge of mechanisms linking innate and adaptive immunity have led to reconsideration of the roles of key players in the pathogenesis of the disease. This review will focus on results from studies performed in vitro and in vivo in patients with psoriasis, and on lessons from recently designed animal models which are considered as the most relevant with respect to the human disease. Even more important, these insights provide a rational basis for the design of new therapeutic strategies aiming at the deletion or the down regulation of activated T cells, or at the suppression of pathogenic cytokines such as TNF-alpha. Some of these new biotherapeutic tools have been successfully used in vivo in clinical trials, providing a confirmation of such concepts.
银屑病是一种常见的慢性炎症性疾病，主要累及皮肤和关节。其皮肤特征性表现包括真皮和表皮的炎症改变，伴有角质形成细胞的异常分化和增殖。近年来，有关该疾病免疫发病机制的研究提供了一系列重要知识。事实上，在连接固有免疫和适应性免疫机制的知识方面的最新进展，促使人们重新审视关键参与者在该疾病发病机制中的作用。本综述将聚焦于对银屑病患者进行的体外和体内研究结果，以及近期设计的被认为与人类疾病最相关的动物模型所带来的启示。更重要的是，这些见解为旨在清除或下调活化T细胞，或抑制致病性细胞因子（如肿瘤坏死因子-α）的新治疗策略的设计提供了合理依据。其中一些新的生物治疗工具已在临床试验中成功用于体内，证实了这些概念。
