Department of Dermatology, Education and Research Centre, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
Arch Dermatol Res. 2011 Dec;303(10):691-705. doi: 10.1007/s00403-011-1169-1. Epub 2011 Aug 24.
Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.
银屑病是一种常见的免疫介导的炎症性皮肤疾病。辅助性 T 细胞（h）1 和 Th17 淋巴细胞通过释放促炎细胞因子促进更多免疫细胞的募集、角质形成细胞增殖和持续炎症，从而促进银屑病的发病机制。先天免疫系统是抵御感染的第一道防线，在启动适应性免疫反应中起着至关重要的作用。先天免疫细胞及其产物在银屑病斑块皮肤中的存在表明先天免疫在这种疾病中发挥作用。此外，先天免疫系统可以指导银屑病中致病性 Th 细胞的发育。在本文中，我们将总结先天免疫系统在银屑病中的作用，特别强调细胞因子、信号通路和先天免疫系统细胞的作用。
