一种新的生物测定法揭示了食螺芋螺毒液中特定于软体动物的毒性。

A new bioassay reveals mollusc-specific toxicity in molluscivorous Conus venoms.

作者信息

Fainzilber M, Zlotkin E

机构信息

Zoology Department, Hebrew University of Jerusalem, Israel.

出版信息

Toxicon. 1992 Apr;30(4):465-9. doi: 10.1016/0041-0101(92)90543-e.

DOI:10.1016/0041-0101(92)90543-e

PMID:1626328

Abstract

Contraction of the foot pedal of a limpet snail is described as a new and quantifiable bioassay for mollusc paralysis. This bioassay was used for screening the venoms of seven different species of Conus snails. Comparison of the results of the limpet assay with those obtained from fish and blowflies shows a correlation between the feeding specificities and venom toxicities of these Conidae. The limpet bioassay should be useful for identification and monitoring of the purification of new toxins active on molluscan systems.

摘要

帽贝蜗牛踏板的收缩被描述为一种用于检测软体动物麻痹的新的可量化生物测定法。这种生物测定法被用于筛选七种不同芋螺的毒液。将帽贝测定结果与从鱼类和家蝇获得的结果进行比较，显示了这些芋螺科动物的捕食特异性与毒液毒性之间的相关性。帽贝生物测定法对于鉴定和监测作用于软体动物系统的新毒素的纯化应该是有用的。