豚鼠离体回肠对海蜗牛带纹芋螺毒液的双相机械反应。
Biphasic mechanical responses of the guinea-pig isolated ileum to the venom of the marine snail Conus striatus.
作者信息
Kobayashi J, Nakamura H, Ohizumi Y
出版信息
Br J Pharmacol. 1981 Jul;73(3):583-5. doi: 10.1111/j.1476-5381.1981.tb16790.x.
Abstract
Venom extract of Conus striatus elicited a rhythmic, transient contraction of the guinea-pig isolated ileum followed by a relaxation at concentrations greater than 1 microgram/ml, which was abolished by tetrodotoxin and a low-Na medium. The contraction induced by the venom was inhibited by atropine but not mecamylamine, whereas the relaxation was not affected by bretylium, guanethidine or phentolamine. These results suggest that the contraction of the ileum induced by the venom is due to the excitation of cholinergic nerves, while the relaxation is mediated through non-adrenergic inhibitory nerves.
摘要
条纹芋螺毒液提取物可引起豚鼠离体回肠有节律的短暂收缩，当浓度大于1微克/毫升时随后出现松弛，这种作用可被河豚毒素和低钠培养基消除。毒液诱导的收缩可被阿托品抑制，但不受美加明抑制，而松弛不受溴苄铵、胍乙啶或酚妥拉明影响。这些结果表明，毒液诱导的回肠收缩是由于胆碱能神经的兴奋，而松弛是通过非肾上腺素能抑制神经介导的。
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