Livingston Gill, Johnston Kate, Katona Cornelius, Paton Joni, Lyketsos Constantine G
Department of Mental Health Sciences, University College London, Holborn Union Building, Archway Campus, Highgate Hill, London, UK, N19 5LW.
Am J Psychiatry. 2005 Nov;162(11):1996-2021. doi: 10.1176/appi.ajp.162.11.1996.
The authors systematically reviewed the literature on psychological approaches to treating the neuropsychiatric symptoms of dementia.
Reports of studies that examined effects of any therapy derived from a psychological approach that satisfied prespecified criteria were reviewed. Data were extracted, the quality of each study was rated, and an overall rating was given to each study by using the Oxford Centre for Evidence-Based Medicine criteria.
A total of 1,632 studies were identified, and 162 satisfied the inclusion criteria for the review. Specific types of psychoeducation for caregivers about managing neuropsychiatric symptoms were effective treatments whose benefits lasted for months, but other caregiver interventions were not. Behavioral management techniques that are centered on individual patients' behavior or on caregiver behavior had similar benefits, as did cognitive stimulation. Music therapy and Snoezelen, and possibly sensory stimulation, were useful during the treatment session but had no longer-term effects; interventions that changed the visual environment looked promising, but more research is needed.
Only behavior management therapies, specific types of caregiver and residential care staff education, and possibly cognitive stimulation appear to have lasting effectiveness for the management of dementia-associated neuropsychiatric symptoms. Lack of evidence regarding other therapies is not evidence of lack of efficacy. Conclusions are limited because of the paucity of high-quality research (only nine level-1 studies were identified). More high-quality investigation is needed.
作者系统回顾了关于治疗痴呆症神经精神症状的心理疗法的文献。
对符合预先设定标准的源自心理疗法的任何治疗效果的研究报告进行了回顾。提取数据,对每项研究的质量进行评级,并使用牛津循证医学中心的标准对每项研究给出总体评级。
共识别出1632项研究,其中162项符合该综述的纳入标准。针对护理人员开展的关于管理神经精神症状的特定类型的心理教育是有效的治疗方法,其益处可持续数月,但其他护理人员干预措施则不然。以个体患者行为或护理人员行为为中心的行为管理技术具有类似的益处,认知刺激也是如此。音乐疗法和多感官环境疗法,以及可能的感官刺激,在治疗期间有用,但没有长期效果;改变视觉环境的干预措施看起来很有前景,但还需要更多研究。
只有行为管理疗法、特定类型的护理人员和机构护理人员教育,以及可能的认知刺激似乎对管理与痴呆症相关的神经精神症状具有持久疗效。缺乏其他疗法的证据并不证明其无效。由于高质量研究匮乏(仅识别出9项一级研究),结论有限。需要更多高质量的调查研究。