Mitchell M, Armstrong D T, Robker R L, Norman R J
Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, Australia, 5011.
Reproduction. 2005 Nov;130(5):583-97. doi: 10.1530/rep.1.00521.
Obesity is associated with a diverse set of metabolic disorders, and has reproductive consequences that are complex and not well understood. The adipose tissue-produced leptin has dominated the literature with regards to female fertility complications, but it is pertinent to explore the likely role of other adipokines--adiponectin and resistin--as our understanding of their biological functions emerge. Leptin influences the developing embryo, the functioning of the ovary and the endometrium, interacts with the release and activity of gonadotrophins and the hormones that control their synthesis. In this review such biological actions and potential roles of the adipokines leptin, adiponectin and resistin are explored in relation to female fertility and the complexity of the obese metabolic state.
肥胖与多种代谢紊乱相关，并且具有复杂且尚未完全了解的生殖后果。在女性生育并发症方面，脂肪组织产生的瘦素在文献中占据主导地位，但随着我们对其他脂肪因子——脂联素和抵抗素——生物学功能的认识不断深入，探讨它们可能发挥的作用是很有必要的。瘦素会影响发育中的胚胎、卵巢和子宫内膜的功能，与促性腺激素的释放和活性以及控制其合成的激素相互作用。在这篇综述中，我们探讨了脂肪因子瘦素、脂联素和抵抗素在女性生育以及肥胖代谢状态复杂性方面的此类生物学作用和潜在作用。
