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血管内支架用于治疗儿童和成人主动脉缩窄:近期和中期结果

Use of endovascular stents for the treatment of coarctation of the aorta in children and adults: immediate and midterm results.

作者信息

Shah Lisa, Hijazi Ziyad, Sandhu Satindir, Joseph Annette, Cao Qi-Ling

机构信息

University of Chicago, Comer Children's Hospital, Chicago, Illinois, USA.

出版信息

J Invasive Cardiol. 2005 Nov;17(11):614-8.

Abstract

OBJECTIVES

The aim of this study was to evaluate the use of endovascular stents in both native and recurrent coarctation of the aorta (CoA) in children and adults.

BACKGROUND

The use of stents in CoA as an alternative to surgery or balloon angioplasty has been shown to have favorable immediate and midterm results.

METHODS

Between May 1995 and February 2005, 44 patients (28 native and 16 with recoarctation after previous intervention) at a mean age of 16.9 +/- 1.8 years (range 3 months to 44 years) underwent stent implantation. Successful outcome was defined as a reduction in the peak systolic pressure gradient by 50% or more.

RESULTS

Stents were implanted in all 44 patients and successful outcomes occurred in all 44 patients. The peak systolic gradient decreased from a mean value of 29.2 +/- 1.9 mmHg (range from 7 to 55 mmHg) to a mean of 3.7 +/- 0.7 mmHg (range from 0 to 18 mmHg). Coarctation site diameter increased from a mean of 6.1 +/- 0.5 mm to a mean of 13 +/- 0.5 mm. Twelve patients underwent stent redilatation/repeat stent placement procedures between 7 to 47.5 months after the initial procedure. One patient underwent a repeat procedure after 1 day secondary to stent migration from the first procedure. Complications occurred in 9 patients, of which no patients required surgery. At a mean follow-up of 19.8 +/- 3.5 months (range 0.1 to 117 months), 1 patient developed an aneurysm at the site of stent implantation. This patient is awaiting surgical repair of the aneurysm. No other complications were noted. Therefore, we conclude that stent implantation for coarctation of the aorta is safe and effective with sustained good midterm results.

摘要

目的

本研究旨在评估血管内支架在儿童和成人原发性及复发性主动脉缩窄(CoA)中的应用。

背景

已证明在CoA中使用支架作为手术或球囊血管成形术的替代方法具有良好的近期和中期效果。

方法

在1995年5月至2005年2月期间,44例平均年龄为16.9±1.8岁(范围3个月至44岁)的患者(28例原发性和16例既往干预后再缩窄)接受了支架植入。成功的结果定义为收缩压峰值梯度降低50%或更多。

结果

44例患者均植入了支架,所有44例患者均获得成功结果。收缩压峰值梯度从平均值29.2±1.9 mmHg(范围7至55 mmHg)降至平均值3.7±0.7 mmHg(范围0至18 mmHg)。缩窄部位直径从平均值6.1±0.5 mm增加到平均值13±0.5 mm。12例患者在初次手术后7至47.5个月接受了支架再扩张/重复支架置入手术。1例患者在初次手术后1天因支架移位接受了重复手术。9例患者出现并发症,其中无患者需要手术。平均随访19.8±3.5个月(范围0.1至117个月)时,1例患者在支架植入部位发生动脉瘤。该患者正在等待动脉瘤的手术修复。未发现其他并发症。因此,我们得出结论,主动脉缩窄的支架植入是安全有效的,中期效果持续良好。

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