Sinning Christoph, Zengin Elvin, Kozlik-Feldmann Rainer, Blankenberg Stefan, Rickers Carsten, von Kodolitsch Yskert, Girdauskas Evaldas
Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
German Center of Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany.
Cardiovasc Diagn Ther. 2018 Dec;8(6):780-788. doi: 10.21037/cdt.2018.09.20.
Prevalence of congenital heart disease (CHD) is constantly increasing during the last decades in line with the treatment options for patients ranging from the surgical as well to the interventional spectrum. This mini-review addresses two of the most common defects with bicuspid aortic valve (BAV) and coarctation of the aorta (CoA). Both diseases are connected to aortic vasculopathy which is one of the most common reasons for morbidity and mortality in young patients with CHD. The review will focus as well on other aspects like medication and treatment of pregnant patients with BAV and CoA. New treatment aspects will be as well reviewed as currently there are additional treatment options to treat aortic regurgitation or aortic aneurysm especially in patients with valvular involvement and a congenital BAV thus avoiding replacement of the aortic valve and potentially improving the future therapy course of the patients.
在过去几十年中,随着针对患者的治疗选择范围从外科手术到介入治疗,先天性心脏病(CHD)的患病率一直在不断上升。本综述探讨了两种最常见的缺陷,即二叶式主动脉瓣(BAV)和主动脉缩窄(CoA)。这两种疾病都与主动脉血管病变有关,而主动脉血管病变是患有CHD的年轻患者发病和死亡的最常见原因之一。该综述还将关注其他方面,如患有BAV和CoA的孕妇的药物治疗和处理。新的治疗方面也将得到综述,因为目前有额外的治疗选择来治疗主动脉反流或主动脉瘤,特别是在涉及瓣膜的患者和先天性BAV患者中,从而避免主动脉瓣置换,并有可能改善患者未来的治疗过程。