Saiz-Bustillo Ramón, Corchero-Martín Guadalupe, García-Montesinos-Perea Belén, Gonzalez-Terán Tomás, Sánchez-Santolino Sergio
Servicio de Cirugía Oral y Maxilofacial, Hospital Universitario Marqués de Valdecilla, Santander.
Med Oral Patol Oral Cir Bucal. 2005 Nov-Dec;10(5):462-7.
The present study was made in order to find possible prognostic factors in oral squamous cell carcinoma, given that it is a frequent disease (3-4% of all malignant tumors) and is the cause of a high morbidity and mortality which justifies any attempt to contribute something towards the understanding of this pathology.
81 oral squamous cell carcinomas, treated with the same procedure, and retrieved from the archive of the Hospital Universitario Marqués de Valdecilla (Santander) were studied. Flow cytometry was carried out on 67 of the samples.
No statistically significant differences were found between the cellular proliferative index and the mitotic index, ploidy and the S-phase factor. Likewise, none of the cytometric variables studied presented any association with the appearance of local relapse, distant metastases or survival.
These variables cannot be used as a prognostic factors in squamous cell carcinomas of the oral cavity.
鉴于口腔鳞状细胞癌是一种常见疾病（占所有恶性肿瘤的3 - 4%），且其发病率和死亡率较高，有必要探索可能的预后因素，因此开展了本研究，这有助于增进对该病理状况的理解。
对81例采用相同治疗方法的口腔鳞状细胞癌病例进行研究，这些病例取自马尔克斯·德·巴尔德西利亚大学医院（桑坦德）的档案库。对其中67个样本进行了流式细胞术检测。
细胞增殖指数与有丝分裂指数、倍体和S期因子之间未发现统计学上的显著差异。同样，所研究的任何细胞计量学变量均与局部复发、远处转移或生存率无关。
这些变量不能用作口腔鳞状细胞癌的预后因素。
