Wang X L
Department of Stomatology, Second Affiliated Hospital of Hebei Medical College, Shijiazhuang.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1990 Jul;25(4):210-2, 251-2.
In an attempt to evaluate the significance of cellular DNA content as an objective prognostic indicator of oral squamous cell carcinomas, a retrospective analysis of 70 paraffin-embedded specimens using flow cytometry was performed. 41 patients (58.6%) had heteroploid tumors and 29 patients (41.4%) had diploid or nearly diploid DNA distribution pattern. There was significant difference in 5-year disease-free rate between patients with heteroploid and diploid or nearly diploid tumors, and the relationship between heteroploid and cervical metastasis approached statistical significance (0.10 greater than P greater than 0.05). The DNA content had no correlation with histologic grade, clinical stage and tumor size. It is concluded that patients with heteroploidy primary tumors have a significantly poorer prognosis than those with diploid or nearly diploid tumors and have higher risk for regional metastasis.
为评估细胞DNA含量作为口腔鳞状细胞癌客观预后指标的意义，采用流式细胞术对70例石蜡包埋标本进行回顾性分析。41例患者（58.6%）肿瘤为异倍体，29例患者（41.4%）DNA分布模式为二倍体或近二倍体。异倍体肿瘤患者与二倍体或近二倍体肿瘤患者的5年无病生存率存在显著差异，异倍体与颈部转移之间的关系接近统计学意义（0.10＞P＞0.05）。DNA含量与组织学分级、临床分期及肿瘤大小无关。结论是，原发性肿瘤为异倍体的患者预后明显比原发性肿瘤为二倍体或近二倍体的患者差，且区域转移风险更高。
