Salvarani Carlo, Casali Bruno, Farnetti Enrico, Pipitone Nicolò, Nicoli Davide, Macchioni Pierluigi, Cimino Luca, Bajocchi Gianluigi, Catanoso Maria Grazia, Boiardi Luigi
Unità Operativa di Reumatologia, Laboratorio di Biologia Molecolare, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
J Rheumatol. 2005 Nov;32(11):2173-7.
To investigate potential associations between the -174 G/C interleukin-6 (IL-6) promoter polymorphism and susceptibility to and clinical features of giant cell arteritis (GCA), particularly in patients with or without polymyalgia rheumatica (PMR) and with or without ischemic complications.
One hundred and twenty-six patients with biopsy-proven GCA who were residents in Reggio Emilia, Italy, and 112 population-based controls from the same geographic area were genotyped for IL-6 polymorphism at position -174 by molecular methods. Patients were divided in subgroups according to presence or absence of PMR and ischemic complications (visual loss, jaw claudication, cerebrovascular accidents, aortic arch syndrome).
Distribution of the G/C 174 genotype was similar in patients with GCA and controls. No significant associations with the IL-6 promoter polymorphism at position -174 were found when GCA patients with or without PMR or with or without ischemic complications were compared. Further, IL-6 genotypes did not significantly affect levels of C-reactive protein or other inflammatory markers at diagnosis.
Our findings show that the 174 G/C promoter IL-6 polymorphism does not seem to be implicated in susceptibility to and clinical expression of GCA.
研究白细胞介素-6（IL-6）基因启动子-174G/C多态性与巨细胞动脉炎（GCA）易感性及临床特征之间的潜在关联，尤其是在伴有或不伴有风湿性多肌痛（PMR）以及伴有或不伴有缺血性并发症的患者中。
采用分子方法对126例经活检证实为GCA的意大利雷焦艾米利亚居民患者以及来自同一地理区域的112名基于人群的对照者进行IL-6基因-174位点多态性基因分型。根据是否存在PMR和缺血性并发症（视力丧失、颌部跛行、脑血管意外、主动脉弓综合征）将患者分为亚组。
GCA患者和对照者中G/C 174基因型的分布相似。在比较伴有或不伴有PMR或伴有或不伴有缺血性并发症的GCA患者时，未发现与-174位点的IL-6启动子多态性有显著关联。此外，IL-6基因型在诊断时对C反应蛋白或其他炎症标志物水平无显著影响。
我们的研究结果表明，IL-6基因启动子174G/C多态性似乎与GCA的易感性和临床表现无关。
