Jung Jae Hyun, Seok Hongdeok, Choi Sung Jae, Song Gwan Gyu, Han Youngjin
Korea University College of Medicine, Seoul, Korea.
Division of Rheumatology, Department of Internal Medicine, Korea University Ansan Hospital, Gyeonggi-do, Korea.
Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(4):302-310. doi: 10.36141/svdld.v36i4.8653. Epub 2019 May 1.
Interleukin (IL)-6 is associated with the development and progression of vasculitis, and inhibitors of this cytokine are used to treat this disease. Polymorphisms of the promoter region of are associated with the production and expression of IL-6. The aim of this study was to perform a meta-analysis of eligible studies to derive a precise estimate of the association between polymorphisms and susceptibility to vasculitis. A meta-analysis was conducted to identify the associations between rs1800795 (-174 G/C) polymorphisms and vasculitis. A total of 13 studies involving 1,294 vasculitis patients and 1,594 controls were considered in the meta-analysis. There were significant associations between rs1800795 polymorphisms and vasculitis in allele contrast, dominant genetic model, and heterozygote vs. dominant homozygote comparison (OR 0.80, 95% CI 0.67-0.94, =0.009 and OR 0.76, 95% CI 0.63-0.92, =0.005, respectively). In subgroup analysis based on subtype, there were significant associations between polymorphisms and susceptibility in large and medium vessel vasculitis, but not in small and variable vessel vasculitis. The GC genotype of rs1800795 was suggested by the analyses to be related to low prevalence of vasculitis, especially for large and medium vessels.
白细胞介素（IL）-6与血管炎的发生和发展相关，该细胞因子的抑制剂可用于治疗这种疾病。IL-6启动子区域的多态性与IL-6的产生和表达有关。本研究的目的是对符合条件的研究进行荟萃分析，以精确估计IL-6多态性与血管炎易感性之间的关联。进行荟萃分析以确定IL-6 rs1800795（-174 G/C）多态性与血管炎之间的关联。荟萃分析共纳入了13项研究，涉及1294例血管炎患者和1594例对照。在等位基因对比、显性遗传模型以及杂合子与显性纯合子比较中，IL-6 rs1800795多态性与血管炎之间存在显著关联（OR分别为0.80，95%CI为0.67-0.94，P=0.009；OR为0.76，95%CI为0.63-0.92，P=0.005）。在基于亚型的亚组分析中，IL-6多态性与大中血管血管炎的易感性之间存在显著关联，但与小血管和可变血管血管炎无关。分析表明，IL-6 rs1800795的GC基因型与血管炎的低患病率相关，尤其是对于大中血管。
