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[结直肠癌。发病率及危险因素]

[Colorectal cancer. Incidence and risk factors].

作者信息

Nørgaard Mette, Iversen Lene Hjerrild, Sørensen Henrik Toft

机构信息

Arhus Universitetshospital, Aalborg Sygehus, Klinisk Epidemiologisk Afdeling, Aalborg.

出版信息

Ugeskr Laeger. 2005 Oct 31;167(44):4157-9.

Abstract

Colorectal cancer (CRC) is a common cancer in the more developed Western countries. This paper aims to give a review of the established or suspected and potentially modifiable risk factors for CRC. Increased BMI, physical inactivity, tobacco smoking and high alcohol consumption are strongly implicated factors. The precise dietary patterns associated with increased risk are less clear. Use of NSAIDs as well as postmenopausal hormones seems to be associated with a substantially reduced risk of CRC. Altogether, the evidence indicates that primary prevention of CRC is feasible.

摘要

结直肠癌(CRC)在西方较发达的国家是一种常见癌症。本文旨在综述已确定的、疑似的以及潜在可改变的结直肠癌风险因素。体重指数(BMI)升高、缺乏身体活动、吸烟和大量饮酒是密切相关的因素。与风险增加相关的确切饮食模式尚不清楚。使用非甾体抗炎药(NSAIDs)以及绝经后激素似乎与结直肠癌风险大幅降低有关。总体而言,证据表明结直肠癌的一级预防是可行的。

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