Martínez M E, McPherson R S, Levin B, Annegers J F
University of Texas-Houston Health Science Center, School of Public Health 77225, USA.
Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov;4(7):703-7.
Most epidemiological evidence supports the inverse association between use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) and colorectal cancer. Few studies have investigated the relation between use of aspirin and other NSAIDs and adenomatous polyps, which are recognized as precursors of colorectal cancer. We examined the association of adenomatous polyps and the dose and duration of use of aspirin and other NSAIDs in a case-control study of dietary risk factors for colorectal adenomatous polyps. The study population comprised 157 case and 480 control individuals who underwent an endoscopy at collaborating gastroenterology clinics in Houston, TX. Face-to-face interviews were conducted to obtain risk factor data that included information on frequency and duration of use of aspirin and other NSAIDs. Compared to the nonusers, the multivariate odds ratios for individuals who took aspirin and other NSAIDs on a weekly basis and for those who took these once/day or more were 0.77 (95% confidence interval, 0.39-1.55) and 0.36 (95% confidence interval, 0.20-0.63), respectively. Compared to the nonusers, the odds ratio for individuals who used aspirin and other NSAIDs for <5 years was 0.39 (95% confidence interval, 0.39-1.55) and 0.36 (95% confidence interval, 0.20-0.71), and for those who used these for 5 years or more, the odds ratio was 0.60 (95% confidence interval, 0.32-1.14). The results of this study suggest that aspirin and other NSAIDs are associated with a decreased risk for adenomatous polyps. Limited dose-response analyses found that the point estimate decreased with the frequency but not the duration of use of aspirin and other NSAIDs.
大多数流行病学证据支持阿司匹林及其他非甾体抗炎药（NSAIDs）的使用与结直肠癌之间存在负相关。很少有研究调查阿司匹林及其他NSAIDs的使用与腺瘤性息肉（被认为是结直肠癌的前体）之间的关系。在一项关于结直肠腺瘤性息肉饮食风险因素的病例对照研究中，我们研究了腺瘤性息肉与阿司匹林及其他NSAIDs的使用剂量和使用时长之间的关联。研究人群包括157例病例和480例对照个体，他们在德克萨斯州休斯顿的合作胃肠病诊所接受了内窥镜检查。通过面对面访谈获取风险因素数据，其中包括阿司匹林及其他NSAIDs的使用频率和使用时长信息。与未使用者相比，每周服用阿司匹林及其他NSAIDs的个体和每天服用一次或更多次的个体的多变量优势比分别为0.77（95%置信区间，0.39 - 1.55）和0.36（95%置信区间，0.20 - 0.63）。与未使用者相比，使用阿司匹林及其他NSAIDs少于5年的个体的优势比为0.39（95%置信区间，0.39 - 1.55）和0.36（95%置信区间，0.20 - 0.71），而使用这些药物5年或更长时间的个体的优势比为0.60（95%置信区间，0.32 - 1.14）。本研究结果表明，阿司匹林及其他NSAIDs与腺瘤性息肉风险降低相关。有限的剂量反应分析发现，随着阿司匹林及其他NSAIDs使用频率的增加，点估计值降低，但与使用时长无关。
