Schiller C, Fröhlich C-P, Giessmann T, Siegmund W, Mönnikes H, Hosten N, Weitschies W
Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Germany.
Aliment Pharmacol Ther. 2005 Nov 15;22(10):971-9. doi: 10.1111/j.1365-2036.2005.02683.x.
The gastrointestinal transit of sequentially administered capsules was investigated in relation to the availability of fluid along the intestinal lumen by magnetic resonance imaging.
Water-sensitive magnetic resonance imaging was performed on 12 healthy subjects during fasting and 1 h after a meal. Specifiable non-disintegrating capsules were administered at 7, 4 and 1 h prior to imaging.
While food intake reduced the mean fluid volumes in the small intestine (105 +/- 72 mL vs. 54 +/- 41 mL, P < 0.01) it had no significant effect on the mean fluid volumes in the colon (13 +/- 12 mL vs. 18 +/- 26 mL). The mean number of separated fluid pockets increased in both organs after meal (small intestine: 4 vs. 6, P < 0.05; large intestine: 4 vs. 6, P < 0.05). The distribution of capsules between the small and large intestine was strongly influenced by food (colon: 3 vs. 17 capsules, P < 0.01).
The results show that fluid is not homogeneously distributed along the gut, which likely contributes to the individual variability of drug absorption. Furthermore, transport of fluid and solids through the ileocaecal valve is obviously initiated by a meal-induced gastro-ileocaecal reflex.
通过磁共振成像研究依次给药的胶囊在胃肠道中的转运情况与肠腔内液体可用性的关系。
对12名健康受试者在空腹时和进食后1小时进行水敏感磁共振成像。在成像前7、4和1小时给予可指定的不崩解胶囊。
虽然进食减少了小肠中的平均液体量（105±72毫升对54±41毫升，P<0.01），但对结肠中的平均液体量没有显著影响（13±12毫升对18±26毫升）。进食后两个器官中分离的液袋平均数量均增加（小肠：4对6，P<0.05；大肠：4对6，P<0.05）。食物对胶囊在小肠和大肠之间的分布有强烈影响（结肠：3对17粒胶囊，P<0.01）。
结果表明，液体在肠道内分布不均，这可能导致药物吸收的个体差异。此外，液体和固体通过回盲瓣的转运显然是由进食引起的胃-回盲反射启动的。
