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六根肋骨:死亡率的转折点。

Half-a-dozen ribs: the breakpoint for mortality.

作者信息

Flagel Benjamin T, Luchette Fred A, Reed R Lawrence, Esposito Thomas J, Davis Kimberly A, Santaniello John M, Gamelli Richard L

机构信息

Division of Trauma, Critical Care, and Burns, Department of Surgery, Burn Shock Trauma Institute, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.

出版信息

Surgery. 2005 Oct;138(4):717-23; discussion 723-5. doi: 10.1016/j.surg.2005.07.022.

Abstract

BACKGROUND

We hypothesized that the number of rib fractures independently impacted patient pulmonary morbidity and mortality.

METHODS

The National Trauma Data Bank (NTDB, v. 3.0 American College of Surgeons, Chicago, IL) was queried for patients sustaining 1 or more rib fractures. Data abstracted included the number of rib fractures by International Classification of Diseases-9 code, Injury Severity Score, the occurrence of pneumonia, acute respiratory distress syndrome, pulmonary embolus, pneumothorax, aspiration pneumonia, empyema, and associated injuries by abbreviated injury score, the need for mechanical ventilation, number of ventilator days, intensive care unit (ICU) length of stay (LOS), hospital LOS, mortality, and use of epidural analgesia. Statistical analysis was performed using the Student t test and linear regression analysis. Statistical significance was defined as a P value of less than .05.

RESULTS

The NTDB included 731,823 patients. Of these, 64,750 (9%) had a diagnosis of 1 or more fractured ribs. Thirteen percent (n = 8,473) of those with rib fractures developed 13,086 complications, of which 6,292 (48%) were related to a chest-wall injury. Mechanical ventilation was required in 60% of patients for an average of 13 days. Hospital LOS averaged 7 days and ICU LOS averaged 4 days. The overall mortality rate for patients with rib fractures was 10%. The mortality rate increased (P < .02) for each additional rib fracture. The same pattern was seen for the following morbidities: pneumonia (P < .01), acute respiratory distress syndrome (P < .01), pneumothorax (P < .01), aspiration pneumonia (P < .01), empyema (P < .04), ICU LOS (P < .01), and hospital LOS for up to 7 rib fractures (P < .01). An association between increasing hospital LOS and number of rib fractures was not shown (P = .19). Pulmonary embolism also was not related to the number of rib fractures (P = .06). Epidural analgesia was used in 2.2% (n = 1,295) of patients with rib fractures. A reduction in mortality with epidural analgesia was shown at 2, 4, and 6 through 8 rib fractures. The use of epidural analgesia had no impact on the frequency of pulmonary complications. When stratifying data by Injury Severity Score and the presence or absence of rib fractures the mortality rates were similar.

CONCLUSIONS

Increasing the number of rib fractures correlated directly with increasing pulmonary morbidity and mortality. Patients sustaining fractures of 6 or more ribs are at significant risk for death from causes unrelated to the rib fractures. Epidural analgesia was associated with a reduction in mortality for all patients sustaining rib fractures, particularly those with more than 4 fractures, but this modality of treatment appears to be underused.

摘要

背景

我们假设肋骨骨折的数量会独立影响患者的肺部发病率和死亡率。

方法

查询国家创伤数据库(NTDB,第3.0版,美国外科医师学会,伊利诺伊州芝加哥)中发生1处或多处肋骨骨折的患者。提取的数据包括根据国际疾病分类第9版编码的肋骨骨折数量、损伤严重度评分、肺炎、急性呼吸窘迫综合征、肺栓塞、气胸、吸入性肺炎、脓胸的发生情况,以及根据简略损伤评分得出的相关损伤情况、机械通气需求、通气天数、重症监护病房(ICU)住院时间(LOS)、医院住院时间、死亡率和硬膜外镇痛的使用情况。使用学生t检验和线性回归分析进行统计分析。统计学显著性定义为P值小于0.05。

结果

NTDB纳入了731,823例患者。其中,64,750例(9%)诊断为1处或多处肋骨骨折。肋骨骨折患者中有13%(n = 8,473)发生了13,086例并发症,其中6,292例(48%)与胸壁损伤有关。60%的患者需要机械通气,平均通气13天。医院平均住院时间为7天,ICU平均住院时间为4天。肋骨骨折患者的总体死亡率为10%。每增加一处肋骨骨折,死亡率就会升高(P < 0.02)。以下疾病也呈现相同模式:肺炎(P < 0.01)、急性呼吸窘迫综合征(P < 0.01)、气胸(P < 0.01)、吸入性肺炎(P < 0.01)、脓胸(P < 0.04)、ICU住院时间(P < 0.01)以及肋骨骨折达7处及以下时的医院住院时间(P < 0.01)。未显示出医院住院时间增加与肋骨骨折数量之间存在关联(P = 0.19)。肺栓塞也与肋骨骨折数量无关(P = 0.06)。2.2%(n = 1,295)的肋骨骨折患者使用了硬膜外镇痛。在肋骨骨折2处、4处以及6至8处时,硬膜外镇痛显示出死亡率降低。硬膜外镇痛的使用对肺部并发症的发生率没有影响。按损伤严重度评分以及是否存在肋骨骨折对数据进行分层时,死亡率相似。

结论

肋骨骨折数量增加与肺部发病率和死亡率升高直接相关。发生6处或更多肋骨骨折的患者因与肋骨骨折无关的原因面临显著的死亡风险。硬膜外镇痛与所有肋骨骨折患者的死亡率降低相关,尤其是那些骨折超过4处的患者,但这种治疗方式似乎未得到充分利用。

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