内质网的一个基于经验的图谱。

An E-MAP of the ER.

作者信息

Conibear Elizabeth

机构信息

Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver V5Z 4H4, Canada.

出版信息

Cell. 2005 Nov 4;123(3):366-8. doi: 10.1016/j.cell.2005.10.016.

DOI:10.1016/j.cell.2005.10.016

PMID:16269327

Abstract

Genome-wide phenotype mapping has the potential to provide insights into gene function on an unprecedented scale. In this issue of Cell, Schuldiner et al.(2005) show that saturation epistasis analysis of genes implicated in the early secretory pathway in yeast provides a new strategy for uncovering functional relationships using high-throughput genomic data.

摘要

全基因组表型图谱有潜力以前所未有的规模提供对基因功能的见解。在本期《细胞》杂志中，舒尔迪纳等人（2005年）表明，对酵母早期分泌途径中相关基因的饱和上位性分析提供了一种利用高通量基因组数据揭示功能关系的新策略。