Seshasayee Aswin Sai Narain
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK.
In Silico Biol. 2006;6(1-2):127-30.
Protein-protein interaction networks are useful in contextual annotation of protein function and in general to achieve a system-level understanding of cellular behavior. This work reports on the social behavior of the yeast protein-protein interaction network and concludes that it is non-random. This work, while providing an analysis of organization of genes into functional societies, can potentially be useful in assessing the accuracy of contextual gene annotation based on such interaction networks.
蛋白质-蛋白质相互作用网络在蛋白质功能的上下文注释中很有用，并且总体上有助于实现对细胞行为的系统层面理解。这项工作报告了酵母蛋白质-蛋白质相互作用网络的社交行为，并得出其并非随机的结论。这项工作在分析基因如何组织成功能群落的同时，可能有助于评估基于此类相互作用网络的上下文基因注释的准确性。
