Boone Charles, Bussey Howard, Andrews Brenda J
Banting & Best Department of Medical Research and Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College Street, Toronto M5S 3E1, Canada.
Nat Rev Genet. 2007 Jun;8(6):437-49. doi: 10.1038/nrg2085.
The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.
遗传工具和资源的开发与应用，使酿酒酵母的部分遗传相互作用网络得以编制。对该网络的分析正在进行中，已经清晰地展现了强有力维持生物系统的遗传相互作用的性质和规模，以及在分子水平上细胞缓冲是如何实现的。酵母的近期研究已开始明确遗传网络的一般原则，也为后生动物模型系统的类似研究铺平了道路。对遗传相互作用网络的比较性理解有望深入了解一些长期存在的遗传学问题，如数量性状的本质和复杂遗传病的基础。
