Gustiene Olivija, Slapikas Rimvydas, Klumbiene Jūrate, Sakalauskiene Giedre, Kubilius Raimondas, Bagdzeviciūte Sigita, Zaliūnas Remigijus
Clinic of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania.
Medicina (Kaunas). 2005;41(10):867-76.
To assess the prevalence of the metabolic syndrome among middle-aged Kaunas population.
A total of 433 (192 males and 241 females, mean age 38.8+/-0.3 years) asymptomatic individuals have been investigated. Metabolic syndrome was diagnosed using International Diabetes Federation definition criteria - central obesity (the waist circumference > or =94 cm for men and > or =80 cm for women) plus any two of the following four factors: elevated triglycerides (Tg) (> or =1.7 mmol/L), low high-density lipoprotein cholesterol (HDL-C) levels (<1.0 mmol/L for men and <1.3 mmol/L for women), blood pressure (BP) of 130/85 or higher (systolic pressure >130 mmHg or a diastolic pressure >85 mmHg) or hyperglycemia (> or =5.6 mmol/L).
The metabolic syndrome was present in 21.7% (28.1% among males and 16.6% among females) of individuals. Furthermore, 41.1% had an increased waist circumference, 56.4% had elevated BP (130/85 or higher), 31.2% had elevated plasma glucose concentration, 19.9% had low HDL-C cholesterol values and 14.1% had increased Tg values. Significantly higher concentration (1.16 mg/L, alpha<0,001, beta<0.001) of high-sensitivity C-reactive protein has been established in individuals with the metabolic syndrome. An increased concentration (>3 mg/L) of high-sensitivity C-reactive protein was more prevalent (17.3%) in the cohort with metabolic syndrome. Concentration of high-sensitivity C-reactive protein directly correlated with the waist and hips circumference, body mass index, concentration of Tg, glucose and BP.
The prevalence of the metabolic syndrome among middle-aged Kaunas residents was 22%. Metabolic syndrome and central obesity correlated with elevated concentration of high-sensitivity C-reactive protein. Moderately (1-3 mg/L) and severely (>3 mg/L) elevated high-sensitivity C-reactive protein levels increase the chance of metabolic syndrome by 4.15 and 7.39 times, respectively (p=0,000). An innovative approach towards cardiovascular risk assessment integrating traditional cardiovascular risk factors, metabolic syndrome and high-sensitivity C-reactive protein values could improve the risk stratification in asymptomatic middle-aged population.
评估考纳斯中年人群中代谢综合征的患病率。
共对433名（192名男性和241名女性，平均年龄38.8±0.3岁）无症状个体进行了调查。采用国际糖尿病联盟定义标准诊断代谢综合征——中心性肥胖（男性腰围≥94厘米，女性腰围≥80厘米）加以下四个因素中的任意两个：甘油三酯（Tg）升高（≥1.7毫摩尔/升）、高密度脂蛋白胆固醇（HDL-C）水平降低（男性<1.0毫摩尔/升，女性<1.3毫摩尔/升）、血压（BP）为130/85或更高（收缩压>130毫米汞柱或舒张压>85毫米汞柱）或血糖升高（≥5.6毫摩尔/升）。
21.7%的个体存在代谢综合征（男性中为28.1%，女性中为16.6%）。此外，41.1%的人腰围增加，56.4%的人血压升高（130/85或更高），31.2%的人血浆葡萄糖浓度升高，19.9%的人HDL-C胆固醇值降低，14.1%的人Tg值升高。代谢综合征患者体内高敏C反应蛋白浓度显著更高（1.16毫克/升，α<0.001，β<0.001）。高敏C反应蛋白浓度升高（>3毫克/升）在代谢综合征队列中更为普遍（17.3%）。高敏C反应蛋白浓度与腰围、臀围、体重指数、Tg浓度、血糖和血压直接相关。
考纳斯中年居民中代谢综合征的患病率为22%。代谢综合征和中心性肥胖与高敏C反应蛋白浓度升高相关。高敏C反应蛋白水平中度（1 - 3毫克/升）和重度（>3毫克/升）升高分别使代谢综合征的发生几率增加4.15倍和7.39倍（p = 0.000）。一种整合传统心血管危险因素、代谢综合征和高敏C反应蛋白值的创新心血管风险评估方法可改善无症状中年人群的风险分层。
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