Mujica Veronica, Leiva Elba, Icaza Gloria, Diaz Nora, Arredondo Miguel, Moore-Carrasco Rodrigo, Orrego Roxana, Vásquez Marcela, Palomo Ivan
Diabetes and Cardiovascular Program, Maule Health Service, Talca, Chile.
Nutr J. 2008 May 15;7:14. doi: 10.1186/1475-2891-7-14.
Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD). Metabolic Syndrome (MS) is a clustering of metabolic alterations associated to IR; however, there is no international consensus for defining its diagnosis. Our objective was to evaluate the prevalence and characteristics of MS identified by the ATP III and IDF criteria in adults from Talca city.
We studied 1007 individuals, aged 18-74, and residents from Talca. MS subjects were defined according to ATP III (three altered factors) and IDF criteria (patients with waist circumference >80/90 cm (W/M) and two others altered factors).
The prevalence of metabolic syndrome according to the IDF and ATP III criteria was 36.4% and 29.5%, respectively after adjustment for age and sex. The agreement for both criteria was 89%. The prevalence in men was higher than in women for both MS definitions, although not significant. MS probability increased with age, and the highest risk was in the 57-68 age group (ATP-MS) and 53-72 age group (IDF-MS). Hypertension, high triglycerides and abdominal obesity are the most frequent alterations in MS.
MS prevalence in adults was higher when diagnosed with IDF than with ATP criterion; in both, age is directly related with the MS presence. The MS subjects showed higher levels of blood pressure, waist circumference and plasma triglycerides. Considering our results, it is worrisome that one third of our population has a high risk of developing DM2 and CVD in the future.
胰岛素抵抗(IR)是2型糖尿病(DM2)和心血管疾病(CVD)的重要危险因素。代谢综合征(MS)是与IR相关的一组代谢改变;然而,对于其诊断的定义尚无国际共识。我们的目的是评估按照ATP III和IDF标准确定的MS在塔尔卡市成年人中的患病率及特征。
我们研究了1007名年龄在18 - 74岁之间、居住在塔尔卡的居民。MS受试者根据ATP III(三项改变因素)和IDF标准(腰围>80/90 cm(女性/男性)且另有两项改变因素的患者)来定义。
在对年龄和性别进行调整后,根据IDF和ATP III标准,代谢综合征的患病率分别为36.4%和29.5%。两种标准的一致性为89%。对于两种MS定义,男性的患病率均高于女性,尽管差异不显著。MS的患病概率随年龄增加,最高风险出现在57 - 68岁年龄组(ATP - MS)和53 - 72岁年龄组(IDF - MS)。高血压、高甘油三酯和腹部肥胖是MS中最常见的改变。
按照IDF标准诊断时,成年人中MS的患病率高于ATP标准;在这两种标准下,年龄均与MS的存在直接相关。MS受试者的血压、腰围和血浆甘油三酯水平较高。考虑到我们的研究结果,令人担忧的是我们三分之一的人口未来有患DM2和CVD的高风险。